Prevalence and Risk Factors for Rapid Eye Movement-Related Obstructive Sleep Apnea in Children
Issued Date
2022-04-28
Resource Type
eISSN
22962360
Scopus ID
2-s2.0-85130042037
Journal Title
Frontiers in Pediatrics
Volume
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Pediatrics Vol.10 (2022)
Suggested Citation
Chamnanpet S., Tovichien P., Tanphaichitr A., Chotinaiwattarakul W. Prevalence and Risk Factors for Rapid Eye Movement-Related Obstructive Sleep Apnea in Children. Frontiers in Pediatrics Vol.10 (2022). doi:10.3389/fped.2022.869986 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85952
Title
Prevalence and Risk Factors for Rapid Eye Movement-Related Obstructive Sleep Apnea in Children
Author's Affiliation
Other Contributor(s)
Abstract
Objectives: Different pathophysiological mechanisms and the distribution of respiratory events among rapid eye movement (REM) and non-rapid eye movement (NREM) sleep modulate the effect of obstructive sleep apnea (OSA). We aimed to study the prevalence and risk factors for REM-related OSA in children. Study Design: Retrospective, cross-sectional study. Methods: We recruited 366 children with OSA confirmed by polysomnography (PSG) over a 5-year period. REM-related OSA is defined by an obstructive apnea-hypopnea index (OAHI) in the REM sleep ≥2× than during NREM sleep. Results: The prevalence of REM-related OSA in children was 50.3%. Children with REM-related OSA were more likely to be female (P = 0.042), and had lower prevalence of adenotonsillar hypertrophy (P = 0.043) compared with children with other OSA subtypes. Children with REM-related OSA slept longer in the supine position (P = 0.003), had shorter duration of NREM1 sleep (P = 0.018), lower nadir SpO2 (P = 0.005), and a higher oxygen desaturation index 3% (ODI3%) (P = 0.014), and lower arousal index (P = 0.034) compared with other OSA subtypes. Female gender and supine sleep was the independent risk factors for REM-related OSA. Conclusion: The prevalence of REM-related OSA was 50.3%. OAHIREM should be considered as an important parameter in future clinical research studies done in children with OSA.