Plasmodium vivax gametocytes and transmission
1
Issued Date
2022-04-01
Resource Type
ISSN
13835769
eISSN
18730329
Scopus ID
2-s2.0-85119253891
Pubmed ID
34748969
Journal Title
Parasitology International
Volume
87
Rights Holder(s)
SCOPUS
Bibliographic Citation
Parasitology International Vol.87 (2022)
Suggested Citation
Bantuchai S., Imad H., Nguitragool W. Plasmodium vivax gametocytes and transmission. Parasitology International Vol.87 (2022). doi:10.1016/j.parint.2021.102497 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85008
Title
Plasmodium vivax gametocytes and transmission
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs. The efficient transmission of Plasmodium vivax from humans to mosquitoes is a key factor that helps perpetuate malaria in endemic areas. A better understanding of transmission is crucial to the success of elimination efforts. Biological delineation of the parasite transmission process is important for identifying and prioritizing new targets of intervention. Identification of the infectious parasite reservoir in the community is key to devising an effective elimination strategy. Here we describe the fundamental characteristics of P. vivax gametocytes - the dynamics of their production, longevity, and the relationship with the total parasitemia - as well as recent advances in the molecular understanding of parasite sexual development. In relation to malaria elimination, factors influencing the human infectivity and the current evidence for a role of asymptomatic carriers in transmission are presented.