One Year Changes in Body Composition and Musculoskeletal Health Following Metabolic/Bariatric Surgery
3
Issued Date
2025-05-01
Resource Type
ISSN
0021972X
eISSN
19457197
Scopus ID
2-s2.0-105003440118
Pubmed ID
39108088
Journal Title
Journal of Clinical Endocrinology and Metabolism
Volume
110
Issue
5
Start Page
e1598
End Page
e1608
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Endocrinology and Metabolism Vol.110 No.5 (2025) , e1598-e1608
Suggested Citation
Jassil F.C., Papageorgiou M., Mackay E., Carnemolla A., Kingett H., Doyle J., Kirk A., Lewis N., Montagut G., Marvasti P., Brown A., Chaiyasoot K., Zakeri R., Mok J., Wingrove J., Collet T.H., Devalia K., Parmar C., Makaronidis J., Batterham R.L. One Year Changes in Body Composition and Musculoskeletal Health Following Metabolic/Bariatric Surgery. Journal of Clinical Endocrinology and Metabolism Vol.110 No.5 (2025) , e1598-e1608. e1608. doi:10.1210/clinem/dgae496 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109905
Title
One Year Changes in Body Composition and Musculoskeletal Health Following Metabolic/Bariatric Surgery
Author's Affiliation
National Institute for Health and Care Research
Siriraj Hospital
Whittington Health NHS Trust
Université de Genève Faculté de Médecine
University College London Hospitals NHS Foundation Trust
University College London
UCL Queen Square Institute of Neurology
Hôpitaux Universitaires de Genève
Homerton University Hospital NHS Foundation Trust
Siriraj Hospital
Whittington Health NHS Trust
Université de Genève Faculté de Médecine
University College London Hospitals NHS Foundation Trust
University College London
UCL Queen Square Institute of Neurology
Hôpitaux Universitaires de Genève
Homerton University Hospital NHS Foundation Trust
Corresponding Author(s)
Other Contributor(s)
Abstract
Context: There are limited comparative studies between one-anastomosis gastric bypass (OAGB) vs Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on body composition and musculoskeletal health. Objective: To compare changes in body composition, areal bone mineral density (aBMD), muscle strength, and physical function in the first year following OAGB, RYGB, and SG within a UK-based healthcare setting. Methods: This is a secondary analysis of the BARI-LIFESTYLE trial in 119 adults (77% women; mean ± SD age 45.9 ± 10.3 years; body mass index 43.6 ± 5.5 kg/m2) who underwent OAGB (n = 19), RYGB (n = 39), and SG (n = 61). Body composition and aBMD by dual energy x-ray absorptiometry, handgrip strength, sit to stand (STS) test and 6-minute walking test (6MWT) were assessed presurgery and at 12 months postsurgery. Results: OAGB, RYGB, and SG exhibited similar reductions in body weight, body fat, and lean mass (within-group comparisons, P < .001). All surgery types were associated with reductions in aBMD at the total hip, femoral neck, and lumbar spine, which were more pronounced after OAGB and RYGB than after SG (all P < .03), though there was no difference between OAGB and RYGB. Despite reductions in absolute handgrip strength, relative handgrip strength, STS test, and 6MWT improved postsurgery (all P < .02), with no differences by surgical procedure. Conclusion: OAGB, RYGB, and SG resulted in comparable weight loss, changes in body composition and improvements in relative muscle strength and physical function. OAGB and RYGB, compared with SG, led to greater BMD reductions at clinically relevant sites. Future long-term studies should explore whether these BMD reductions translate into a greater fracture risk.