Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity
Issued Date
2023-09-01
Resource Type
ISSN
12019712
eISSN
18783511
Scopus ID
2-s2.0-85160675132
Pubmed ID
37207716
Journal Title
International Journal of Infectious Diseases
Volume
134
Start Page
18
End Page
22
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases Vol.134 (2023) , 18-22
Suggested Citation
Suntronwong N., Kanokudom S., Assawakosri S., Vichaiwattana P., Klinfueng S., Phowatthanasathian H., Chansaenroj J., Srimuan D., Thatsanathorn T., Duangchinda T., Chantima W., Pakchotanon P., Sudhinaraset N., Wanlapakorn N., Poovorawan Y. Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity. International Journal of Infectious Diseases Vol.134 (2023) , 18-22. 22. doi:10.1016/j.ijid.2023.05.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82993
Title
Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity
Other Contributor(s)
Abstract
Objectives: To assess the binding antibody response and strength of neutralization against Omicron BA.5 in serum samples from children with different antigen exposures (infection/vaccination) and hybrid immunity. Methods: This study recruited children aged 5-7 years. All samples were tested for anti-nucleocapsid immunoglobulin (Ig)G, anti-receptor binding domain (RBD) IgG, and total anti-RBD Ig. Neutralizing antibodies (nAbs) against Omicron BA.5 were determined using a focus reduction neutralization test. Results: A total of 196 serum samples from unvaccinated children with infection (n = 57), vaccination alone (n = 71), and hybrid immunity (n = 68). Our results showed that 90% of the samples from children with hybrid immunity, 62.2% from two-dose vaccination, and 48% from Omicron infection alone had detectable nAbs against Omicron BA.5. The highest neutralizing titer was observed in infection plus two-dose vaccination, which reached 6.3-fold increase, whereas nAb titers in two-dose vaccination was comparable to Omicron-infected sera. However, sera from pre-Omicron infection and single-dose vaccination failed to neutralize Omicron BA.5; although, the total anti-RBD Ig were comparable with Omicron-infected sera. Conclusion: This result highlights that hybrid immunity provided cross-reactive antibodies to neutralize Omicron BA.5 compared with either vaccination or infection alone. The finding emphasizes the importance of vaccination in unvaccinated children who are infected with pre-Omicron or Omicron variants.