Differentiation of monocytes during inflammation : an in vitro study on expression of surface markers
1
Issued Date
2024
Copyright Date
1993
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
iv, 61 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pathobiology))--Mahidol University, 1993
Suggested Citation
Sompid Kintarak Differentiation of monocytes during inflammation : an in vitro study on expression of surface markers. Thesis (M.Sc. (Pathobiology))--Mahidol University, 1993. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99134
Title
Differentiation of monocytes during inflammation : an in vitro study on expression of surface markers
Alternative Title(s)
การจำแนกความแตกต่างของโมโนไซท์ขณะมีการอักเสบโดยศึกษาการแสดงออกของแอนติเจนบนผิวเซลล์
Author(s)
Advisor(s)
Abstract
Various surface markers of monocytes and differentiating macrophages (in vitro) of both healthy volunteers and adult periodontitis patients with localized periodontal abscess formation were investigated by flow cytometry. In healthy volunteers, a relative expression of the markers on monocytes/macrophages differed dramatically during 7 days of culture. In the presence of lymphocytes, the differentiating macrophages did. not reach the same state of differentiation as those macrophages cultured wit ocytes. Macrophages co-cultured with lymphocytes showed decreased expression of CD14, CD11c and CD71. This suggests that one of the mechanisms which lymphocytes can modulate the immune system is via regulation of monocytes/macrophages differentiation. In periodontitis, differentiating macrophages expressed adhesion proteins (CD11a, CD54), differentiation antigens (CD11c, CD36 and CD71) and HLA-DR in a relatively higher quantity than in the healthy group. Results from this study may explain the responsive of monocytes in periodontitis patients during exposure to microorganism and/or its products.
Description
Pathobiology (Mahidol University 1993)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pathobiology
Degree Grantor(s)
Mahidol University