Dose-dependent effect of impaired renal function on all-cause mortality in patients following percutaneous coronary intervention
Issued Date
2022-08-01
Resource Type
ISSN
01609289
eISSN
19328737
Scopus ID
2-s2.0-85132804112
Pubmed ID
35758306
Journal Title
Clinical Cardiology
Volume
45
Issue
8
Start Page
882
End Page
891
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Cardiology Vol.45 No.8 (2022) , 882-891
Suggested Citation
Limpijankit T., Chandavimol M., Srimahachota S., Kanoksilp A., Jianmongkol P., Siriyotha S., Thakkinstian A., Buddhari W., Sansanayudh N. Dose-dependent effect of impaired renal function on all-cause mortality in patients following percutaneous coronary intervention. Clinical Cardiology Vol.45 No.8 (2022) , 882-891. 891. doi:10.1002/clc.23877 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85684
Title
Dose-dependent effect of impaired renal function on all-cause mortality in patients following percutaneous coronary intervention
Other Contributor(s)
Abstract
Objective: To determine the risk prediction of various degrees of impaired renal function on all-cause mortality in patients following percutaneous coronary intervention (PCI). Background: Patients with chronic kidney disease (CKD) are at high risk of all-cause mortality after PCI. However, there are less data of various degrees of impaired renal function to predict those risks. Methods: This was a subgroup analysis of nationwide PCI registry of 22 045 patients. Patients were classified into six CKD stages according to preprocedure estimated glomerular filtration rate (eGFR) (ml/min/1.73 m2): I (≥90), II (60−89), III (30−59), IV (15−29), or V (<15) without or with dialysis. Baseline clinical and angiographic characteristics were compared among patients in each stage. One-year all-cause mortality was reported with risk prediction based on CKD stages and other risk factors. Results: Patients with CKD stage I−V without and with on dialysis were found in 26.9%, 40.8%, 23.2%, 3.9%, 1.5%, and 3.7%, respectively. PCI procedural success and complication rates ranged from 94.0% to 96.2% and 2.8% to 6.1%, respectively. One-year overall survival among CKD stages I−V was 96.3%, 93.1%, 84.4%, 65.2%, 68.0%, and 69.4%, respectively (p <.001 by log-rank test). After adjusting covariables, the hazard ratios of all-cause mortality for CKD stages II−V as compared to stage I by multivariate Cox regression analysis were 1.5, 2.6, 5.3, 5.9, and 7.0, respectively, (p <.001). Conclusion: Among patients undergoing PCI, lower preprocedure eGFR is associated in a dose-dependent effect with decreased 1-year survival. This finding may be useful for risk classification and to guide decision-making.