A quarter-century report on neuromyelitis optica spectrum disorder in Thailand: A single-center tertiary care cohort
Issued Date
2022-07-01
Resource Type
ISSN
22110348
eISSN
22110356
Scopus ID
2-s2.0-85130785466
Pubmed ID
35636272
Journal Title
Multiple Sclerosis and Related Disorders
Volume
63
Rights Holder(s)
SCOPUS
Bibliographic Citation
Multiple Sclerosis and Related Disorders Vol.63 (2022)
Suggested Citation
Tisavipat N. A quarter-century report on neuromyelitis optica spectrum disorder in Thailand: A single-center tertiary care cohort. Multiple Sclerosis and Related Disorders Vol.63 (2022). doi:10.1016/j.msard.2022.103907 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85768
Title
A quarter-century report on neuromyelitis optica spectrum disorder in Thailand: A single-center tertiary care cohort
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating astrocytopathy with a high relapse-related disability. This is the largest long-term study of Thai NMOSD patients. Objectives: To compare characteristics and outcomes of aquaporin 4 (AQP4)-IgG-positive and AQP4-IgG-negative patients. Methods: A retrospective review of NMOSD patients at a university hospital was performed from January 1994 to July 2021. Results: From 165 NMSOD patients, the overall female-to-male ratio was 14:1. The mean onset age was 37.5 ± 14.3 years, and the median disease duration was 10.2 years. Transverse myelitis (46.1%) and optic neuritis (39.4%) were the most common presentations. Around 60% remained fully ambulatory at the last follow-up. Severe visual loss and ambulation aids were comparable in both groups, but the AQP4-IgG-positive had severe bowel and/or bladder dysfunction more often than the AQP4-IgG-negative (p = 0.026). The mortality rate was 6.7%, mainly from infection. Multivariate analysis showed that longer time-to-diagnosis and higher disability scores were associated with death. Diagnosis within one year yielded better visual and motor outcomes and lower annualized relapse rate. Conclusions: Thai AQP4-IgG-positive and AQP4-IgG-negative NMOSD patients had similar baseline characteristics. Relapse and mortality rates were comparable to global NMOSD patients. Diagnosis within one year promises better outcomes.
