Subacute Cutaneous Lupus Erythematosus-Like Eruption Induced by Durvalumab: A Case Report and Literature Review
Issued Date
2022-01-01
Resource Type
eISSN
11787015
Scopus ID
2-s2.0-85123839470
Journal Title
Clinical, Cosmetic and Investigational Dermatology
Volume
15
Start Page
51
End Page
62
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical, Cosmetic and Investigational Dermatology Vol.15 (2022) , 51-62
Suggested Citation
Pratumchart N. Subacute Cutaneous Lupus Erythematosus-Like Eruption Induced by Durvalumab: A Case Report and Literature Review. Clinical, Cosmetic and Investigational Dermatology Vol.15 (2022) , 51-62. 62. doi:10.2147/CCID.S344445 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86677
Title
Subacute Cutaneous Lupus Erythematosus-Like Eruption Induced by Durvalumab: A Case Report and Literature Review
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Reports of immune-related adverse events caused by programmed cell death-ligand 1 (PD-L1) inhibitor have been emerging. Herein, we report a subacute cutaneous lupus erythematosus (SCLE)-like eruption presented after the treatment of durvalumab in a patient with extensive-stage small cell lung carcinoma. A 74-year-old Thai man was referred to our department after experiencing multiple dusky red to brownish papules and patches with scale and erosions on photo-distributed areas after receiving 3 infusion cycles of durvalumab. Histological finding revealed epidermal atrophy with interface changes and superficial perivascular infiltration of lymphocytes. Serum antinuclear antibodies (ANA) was 1:320 and anti-Ro/Sjogren’s-syndrome-related antigen A (anti-Ro/SSA) antibodies were positive (2+). Based on the history and clinicopathological correlation, the diagnosis of SCLE-like eruption due to durvalumab was made. To the best of our knowledge, this is the first case of durvalumab-induced SCLE.