Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS)
Issued Date
2022-05-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85131018617
Pubmed ID
35609049
Journal Title
PLoS ONE
Volume
17
Issue
5 May
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.17 No.5 May (2022)
Suggested Citation
Kanjanabuch T., Nopsopon T., Chatsuwan T., Purisinsith S., Johnson D.W., Udomsantisuk N., Halue G., Lorvinitnun P., Puapatanakul P., Pongpirul K., Poonvivatchaikarn U., Tatiyanupanwong S., Chowpontong S., Chieochanthanakij R., Thamvichitkul O., Treamtrakanpon W., Saikong W., Parinyasiri U., Chuengsaman P., Dandecha P., Perl J., Tungsanga K., Eiam-Ong S., Sritippayawan S., Kantachuvesiri S., Chittinandana A., Wongsawan D., Boonyakrai C., Siriwong D., Siribamrungwong M., Kingwatanakul P., Jaturapisanukul S., Yongsiri S., Narenpitak S., Limlek T., Eiamsitrakoon T., Suteeka Y., Boongird S., Khositrangsikun K., Wongluechai L. Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS). PLoS ONE Vol.17 No.5 May (2022). doi:10.1371/journal.pone.0268823 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86510
Title
Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS)
Author(s)
Kanjanabuch T.
Nopsopon T.
Chatsuwan T.
Purisinsith S.
Johnson D.W.
Udomsantisuk N.
Halue G.
Lorvinitnun P.
Puapatanakul P.
Pongpirul K.
Poonvivatchaikarn U.
Tatiyanupanwong S.
Chowpontong S.
Chieochanthanakij R.
Thamvichitkul O.
Treamtrakanpon W.
Saikong W.
Parinyasiri U.
Chuengsaman P.
Dandecha P.
Perl J.
Tungsanga K.
Eiam-Ong S.
Sritippayawan S.
Kantachuvesiri S.
Chittinandana A.
Wongsawan D.
Boonyakrai C.
Siriwong D.
Siribamrungwong M.
Kingwatanakul P.
Jaturapisanukul S.
Yongsiri S.
Narenpitak S.
Limlek T.
Eiamsitrakoon T.
Suteeka Y.
Boongird S.
Khositrangsikun K.
Wongluechai L.
Nopsopon T.
Chatsuwan T.
Purisinsith S.
Johnson D.W.
Udomsantisuk N.
Halue G.
Lorvinitnun P.
Puapatanakul P.
Pongpirul K.
Poonvivatchaikarn U.
Tatiyanupanwong S.
Chowpontong S.
Chieochanthanakij R.
Thamvichitkul O.
Treamtrakanpon W.
Saikong W.
Parinyasiri U.
Chuengsaman P.
Dandecha P.
Perl J.
Tungsanga K.
Eiam-Ong S.
Sritippayawan S.
Kantachuvesiri S.
Chittinandana A.
Wongsawan D.
Boonyakrai C.
Siriwong D.
Siribamrungwong M.
Kingwatanakul P.
Jaturapisanukul S.
Yongsiri S.
Narenpitak S.
Limlek T.
Eiamsitrakoon T.
Suteeka Y.
Boongird S.
Khositrangsikun K.
Wongluechai L.
Author's Affiliation
Ramathibodi Hospital
Siriraj Hospital
Translation Research Institute Australia
Chaiyapoom Hospital
Bangkok Metropolitan Administration
The University of Queensland
Chulalongkorn University
Songkhla Hospital
Faculty of Medicine, Prince of Songkia University
Princess Alexandra Hospital
Bhumibol Adulyadej Hospital
Lerdsin Hospital
King Chulalongkorn Memorial Hospital
Vajira Hospital
Khon Kaen University
Saint Michael's Hospital University of Toronto
Taksin Hospital
Thammasat University
Burapha University
Sawanpracharak Hospital
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Dialysis Policy and Practice Program (Di3P)
Center of Excellence in Kidney Metabolic Disorders
Banphaeo Hospital
Phra Nakhon Si Ayutthaya Hospital
Maharat Nakhon Ratchasima Hospital
Nakhon Pathom Hospital
Sunpasitthiprasong Hospital
Krabi Hospital
Sisaket Hospital
Maharaj Nakhon Si Thammarat Hospital
Udonthani Hospital
Chaophraya Abhaibhubejhr Hospital
Phayao Hospital
Division of Nephrology
Mukdahan Hospital
Siriraj Hospital
Translation Research Institute Australia
Chaiyapoom Hospital
Bangkok Metropolitan Administration
The University of Queensland
Chulalongkorn University
Songkhla Hospital
Faculty of Medicine, Prince of Songkia University
Princess Alexandra Hospital
Bhumibol Adulyadej Hospital
Lerdsin Hospital
King Chulalongkorn Memorial Hospital
Vajira Hospital
Khon Kaen University
Saint Michael's Hospital University of Toronto
Taksin Hospital
Thammasat University
Burapha University
Sawanpracharak Hospital
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Dialysis Policy and Practice Program (Di3P)
Center of Excellence in Kidney Metabolic Disorders
Banphaeo Hospital
Phra Nakhon Si Ayutthaya Hospital
Maharat Nakhon Ratchasima Hospital
Nakhon Pathom Hospital
Sunpasitthiprasong Hospital
Krabi Hospital
Sisaket Hospital
Maharaj Nakhon Si Thammarat Hospital
Udonthani Hospital
Chaophraya Abhaibhubejhr Hospital
Phayao Hospital
Division of Nephrology
Mukdahan Hospital
Other Contributor(s)
Abstract
Introduction We sought to evaluate the predictors and outcomes of mold peritonitis in patients with peritoneal dialysis (PD). Methods This cohort study included PD patients from the MycoPDICS database who had fungal peritonitis between July 2015-June 2020. Patient outcomes were analyzed by Kaplan Meier curves and the Log-rank test. Multivariable Cox proportional hazards model regression was used to estimating associations between fungal types and patients’ outcomes. Results The study included 304 fungal peritonitis episodes (yeasts n = 129, hyaline molds n = 122, non-hyaline molds n = 44, and mixed fungi n = 9) in 303 patients. Fungal infections were common during the wet season (p <0.001). Mold peritonitis was significantly more frequent in patients with higher hemoglobin levels, presentations with catheter problems, and positive galactomannan (a fungal cell wall component) tests. Patient survival rates were lowest for non-hyaline mold peritonitis. A higher hazard of death was significantly associated with leaving the catheter in-situ (adjusted hazard ratio [HR] = 6.15, 95%confidence interval [CI]: 2.86–13.23) or delaying catheter removal after the diagnosis of fungal peritonitis (HR = 1.56, 95%CI: 1.00–2.44), as well as not receiving antifungal treatment (HR = 2.23, 95%CI: 1.25–4.01) or receiving it for less than 2 weeks (HR = 2.13, 95%CI: 1.33–3.43). Each additional day of antifungal therapy beyond the minimum 14-day duration was associated with a 2% lower risk of death (HR = 0.98, 95%CI: 0.95–0.999). Conclusion Non-hyaline-mold peritonitis had worse survival. Longer duration and higher daily dosage of antifungal treatment were associated with better survival. Deviations from the 2016 ISPD Peritonitis Guideline recommendations concerning treatment duration and catheter removal timing were independently associated with higher mortality.