Marine bioactive compounds as antibiofilm agent: a metabolomic approach
Issued Date
2023-01-01
Resource Type
ISSN
03028933
eISSN
1432072X
Scopus ID
2-s2.0-85145668633
Pubmed ID
36602609
Journal Title
Archives of Microbiology
Volume
205
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of Microbiology Vol.205 No.1 (2023)
Suggested Citation
Lahiri D., Nag M., Dey A., Sarkar T., Pati S., Nirmal N.P., Ray R.R., Upadhye V.J., Pandit S., Moovendhan M., Kavisri M. Marine bioactive compounds as antibiofilm agent: a metabolomic approach. Archives of Microbiology Vol.205 No.1 (2023). doi:10.1007/s00203-022-03391-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81982
Title
Marine bioactive compounds as antibiofilm agent: a metabolomic approach
Other Contributor(s)
Abstract
The ocean is a treasure trove of both living and nonliving creatures, harboring incredibly diverse group of organisms. A plethora of marine sourced bioactive compounds are discovered over the past few decades, many of which are found to show antibiofilm activity. These are of immense clinical significance since the formation of microbial biofilm is associated with the development of high antibiotic resistance. Biofilms are also responsible to bring about problems associated with industries. In fact, the toilets and wash-basins also show degradation due to development of biofilm on their surfaces. Antimicrobial resistance exhibited by the biofilm can be a potent threat not only for the health care unit along with industries and daily utilities. Various recent studies have shown that the marine members of various kingdom are capable of producing antibiofilm compounds. Many such compounds are with unique structural features and metabolomics approaches are essential to study such large sets of metabolites. Associating holobiome metabolomics with analysis of their chemical attribute may bring new insights on their antibiofilm effect and their applicability as a substitute for conventional antibiotics. The application of computer-aided drug design/discovery (CADD) techniques including neural network approaches and structured-based virtual screening, ligand-based virtual screening in combination with experimental validation techniques may help in the identification of these molecules and evaluation of their drug like properties.
