Diversity of carbapenemase genes among carbapenem resistant Klebsiella pneumoniae in a tertiary care hospital in Bangkok, Thailand
Issued Date
2025-06-20
Resource Type
eISSN
15882640
Scopus ID
2-s2.0-105009656931
Pubmed ID
40493394
Journal Title
Acta Microbiologica Et Immunologica Hungarica
Volume
72
Issue
2
Start Page
119
End Page
126
Rights Holder(s)
SCOPUS
Bibliographic Citation
Acta Microbiologica Et Immunologica Hungarica Vol.72 No.2 (2025) , 119-126
Suggested Citation
Homkaew A., Wongsuk T., Boonsilp S., Ckumdee J., Dubbs P., Palittapongarnpim P. Diversity of carbapenemase genes among carbapenem resistant Klebsiella pneumoniae in a tertiary care hospital in Bangkok, Thailand. Acta Microbiologica Et Immunologica Hungarica Vol.72 No.2 (2025) , 119-126. 126. doi:10.1556/030.2025.02599 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111165
Title
Diversity of carbapenemase genes among carbapenem resistant Klebsiella pneumoniae in a tertiary care hospital in Bangkok, Thailand
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Abstract
Multidrug resistant (MDR) gram-negative bacilli associated with hospital-acquired infections are commonly resistant to carbapenems. Klebsiella pneumoniae is a common MDR Enterobacterales in Thailand. In this study, we investigated the distribution of five carbapenemase genes (blaNDM, blaOXA-48, blaIMP, blaVIM, and blaKPC) among 62 carbapenem resistant K. pneumoniae (CRKP) collected in 2022 from patients admitted to a tertiary care hospital in Bangkok. The frequencies of isolates carrying a single carbapenamase gene were 39% for blaOXA-48 and 19% for blaNDM. Interestingly the frequency of the carriers of both genes was as high as 29% and none of the isolates carried blaKPC, commonly reported elsewhere. The studied genes were not identified in 7 isolates (11%). CRKP carrying blaNDM was more frequently identified in medical wards, associated with higher mortality rate and 100% resistant to ceftazidime/avibactam while the one carrying only blaOXA-48 was 92% susceptible to ceftazidime/avibactam. This study confirms the advantage of molecular methods for differentiating between mechanisms of carbapenem resistance in K. pneumoniae.