Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques
Issued Date
2023-11-30
Resource Type
eISSN
10985514
Scopus ID
2-s2.0-85178497610
Pubmed ID
37846984
Journal Title
Journal of virology
Volume
97
Issue
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of virology Vol.97 No.11 (2023) , e0096323
Suggested Citation
Keelapang P., Ketloy C., Puttikhunt C., Sriburi R., Prompetchara E., Sae-Lim M., Siridechadilok B., Duangchinda T., Noisakran S., Charoensri N., Suriyaphol P., Suparattanagool P., Utaipat U., Masrinoul P., Avirutnan P., Mongkolsapaya J., Screaton G., Auewarakul P., Malaivijitnond S., Yoksan S., Malasit P., Ruxrungtham K., Pulmanausahakul R., Sittisombut N. Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques. Journal of virology Vol.97 No.11 (2023) , e0096323. doi:10.1128/jvi.00963-23 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/91433
Title
Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques
Author(s)
Keelapang P.
Ketloy C.
Puttikhunt C.
Sriburi R.
Prompetchara E.
Sae-Lim M.
Siridechadilok B.
Duangchinda T.
Noisakran S.
Charoensri N.
Suriyaphol P.
Suparattanagool P.
Utaipat U.
Masrinoul P.
Avirutnan P.
Mongkolsapaya J.
Screaton G.
Auewarakul P.
Malaivijitnond S.
Yoksan S.
Malasit P.
Ruxrungtham K.
Pulmanausahakul R.
Sittisombut N.
Ketloy C.
Puttikhunt C.
Sriburi R.
Prompetchara E.
Sae-Lim M.
Siridechadilok B.
Duangchinda T.
Noisakran S.
Charoensri N.
Suriyaphol P.
Suparattanagool P.
Utaipat U.
Masrinoul P.
Avirutnan P.
Mongkolsapaya J.
Screaton G.
Auewarakul P.
Malaivijitnond S.
Yoksan S.
Malasit P.
Ruxrungtham K.
Pulmanausahakul R.
Sittisombut N.
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
Faculty of Medicine, Khon Kaen University
Chulabhorn Royal Academy
Khon Kaen University
Thailand National Center for Genetic Engineering and Biotechnology
Institute of Molecular Biosciences, Mahidol University
Nuffield Department of Medicine
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
Faculty of Medicine, Khon Kaen University
Chulabhorn Royal Academy
Khon Kaen University
Thailand National Center for Genetic Engineering and Biotechnology
Institute of Molecular Biosciences, Mahidol University
Nuffield Department of Medicine
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Other Contributor(s)
Abstract
IMPORTANCE: Currently licensed dengue vaccines do not induce long-term protection in children without previous exposure to dengue viruses in nature. These vaccines are based on selected attenuated strains of the four dengue serotypes and employed in combination for two or three consecutive doses. In our search for a better dengue vaccine candidate, live attenuated strains were followed by non-infectious virus-like particles or the plasmids that generate these particles upon injection into the body. This heterologous prime-boost immunization induced elevated levels of virus-specific antibodies and helped to prevent dengue virus infection in a high proportion of vaccinated macaques. In macaques that remained susceptible to dengue virus, distinct mechanisms were found to account for the immunization failures, providing a better understanding of vaccine actions. Additional studies in humans in the future may help to establish whether this combination approach represents a more effective means of preventing dengue by vaccination.