Organomegalies as a predictive indicator of leukemia cutis in patients with acute myeloid leukemia
Issued Date
2024-02-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85185315672
Pubmed ID
38363781
Journal Title
PLoS ONE
Volume
19
Issue
2 February
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.19 No.2 February (2024)
Suggested Citation
Kanitthamniyom C., Wannaphut C., Pattanaprichaku P., Kungwankiattichi S., Owattanapanich W. Organomegalies as a predictive indicator of leukemia cutis in patients with acute myeloid leukemia. PLoS ONE Vol.19 No.2 February (2024). doi:10.1371/journal.pone.0297805 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/97325
Title
Organomegalies as a predictive indicator of leukemia cutis in patients with acute myeloid leukemia
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Abstract
Background Leukemia cutis (LC) is an extramedullary acute myeloid leukemia (AML) infiltrate. No previous study has described the clinical characteristics and outcomes of Thai patients diagnosed with AML with LC. Materials and methods We conducted a 7-year retrospective case-control study on Thai AML patients at Siriraj Hospital from November 2013 to July 2020. Patients were divided into LC and non-LC groups. Initial clinical presentations and laboratory findings were examined to identify LC-associated factors. Overall survival (OS) and relapse-free survival (RFS) were assessed. Pathological tissues underwent re-evaluation to validate the LC diagnoses. Results The study included 159 patients in a 2:1 ratio (106 non-LC and 53 LC). The LC group had a mean ± SD age of 54.3 ± 15.5 years; females were predominant. Three-fifths of the LC patients had intermediate-risk cytogenetics; 20.4% had an adverse risk, and 10.2% had a favorable risk. Most were classified as AML-M4 and AML-M5. Leukemic nodules were the primary finding in 58.5% of the cases, mainly on the legs. In the multivariate analysis of predictive factors associated with LC, organomegalies, specifically hepatomegaly, and lymphadenopathy, remained significant factors associated with LC [OR 4.45 (95%CI 1.20, 16.50); p = 0.026 and OR 5.48 (95%CI 1.65, 18.20); p = 0.005], respectively. The LC group demonstrated a significantly reduced OS (log-rank test p = 0.002) (median OS of 8.6 months vs. 32.4 months). RFS was considerably lower in the LC group (log-rank test p = 0.001) (median duration of 10.3 months vs. 24.4 months in the non-LC). Conclusions AML patients who developed LC tended to experience notably poorer prognoses. Therefore, it is imperative to consider aggressive treatment options for such individuals. The presence of organomegalies in AML patients serves as a strong predictor of the possible occurrence of LC when accompanied by skin lesions.