Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs
Issued Date
2022-11-01
Resource Type
ISSN
16617827
eISSN
16604601
Scopus ID
2-s2.0-85142471532
Pubmed ID
36429432
Journal Title
International Journal of Environmental Research and Public Health
Volume
19
Issue
22
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Environmental Research and Public Health Vol.19 No.22 (2022)
Suggested Citation
Sasivimolrattana T., Chantratita W., Sensorn I., Chaiwongkot A., Oranratanaphan S., Bhattarakosol P., Bhattarakosol P. Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs. International Journal of Environmental Research and Public Health Vol.19 No.22 (2022). doi:10.3390/ijerph192214716 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84660
Title
Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs
Author's Affiliation
Other Contributor(s)
Abstract
Human papillomavirus type 16 (HPV16) and/or high-risk (Hr-) HPV are the main causes of cervical cancer. Another element that may contribute to the development of cervical cancer is the microbiota. To date, no study has investigated the entire cervical microbiome, which consists of bacteria, fungi, and viruses. In this study, cervical samples with different histopathology (CIN1, CIN2, and CIN3), with or without HPV16 and Hr-HPVs infection, were enrolled. From bacterial community analysis, 115 bacterial species were found and separated into 2 distinct categories based on Lactobacillus abundance: Lactobacilli-dominated (LD) and non-Lactobacilli-dominated (NLD) groups. The LD group had significantly less bacterial diversity than the NLD group. In addition, the variety of bacteria was contingent on the prevalence of HPV infection. Among distinct histological groups, an abundance of L. iners (>60% of total Lactobacillus spp.) was discovered in both groups. A few fungi, e.g., C. albicans, were identified in the fungal community. The viral community analysis revealed that the presence of HPV considerably reduced the diversity of human viruses. Taken together, when we analyzed all our results collectively, we discovered that HPV infection was a significant determinant in the diversity of bacteria and human viruses in the cervix.