Insights into molecular mechanisms of phytochemicals in quorum sensing modulation for bacterial biofilm control
Issued Date
2024-11-05
Resource Type
eISSN
1432072X
Scopus ID
2-s2.0-85208603021
Pubmed ID
39499335
Journal Title
Archives of microbiology
Volume
206
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of microbiology Vol.206 No.12 (2024) , 459
Suggested Citation
Nguyen A.N.X., Thirapanmethee K., Audshasai T., Khuntayaporn P., Chomnawang M.T. Insights into molecular mechanisms of phytochemicals in quorum sensing modulation for bacterial biofilm control. Archives of microbiology Vol.206 No.12 (2024) , 459. doi:10.1007/s00203-024-04171-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102050
Title
Insights into molecular mechanisms of phytochemicals in quorum sensing modulation for bacterial biofilm control
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Corresponding Author(s)
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Abstract
Biofilm formation is a common mechanism by which bacteria undergo phenotypic changes to adapt to environmental stressors. The formation of biofilms has a detrimental impact in clinical settings by contributing to chronic infections and promoting antibiotic resistance. Delving into the molecular mechanisms, the quorum sensing (QS) system involves the release of chemical signals for bacterial cell-to-cell communication, which activates and regulates the expression of various genes and virulence factors, including those related to biofilm formation. Accordingly, the QS system becomes a potential target for combating biofilm-associated concerns. Natural products derived from plants have a long history of treating infectious diseases in humans due to their antimicrobial properties, making them valuable resources for screening anti-biofilm agents. This review aims to discover the mechanisms by which phytochemical agents inhibit QS, potentially offering promising new therapies for treating biofilm-associated infections. By targeting the QS system, these phytochemical agents can prevent bacterial aggregation and biofilm formation while also diminishing other bacterial virulence factors. Additionally, it is important to focus on the advancement of techniques and experiments to investigate their molecular mechanisms. A thorough understanding of these mechanisms may encourage further studies to evaluate the safety and efficacy of phytochemical agents used alone or in combination with other strategies.