Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum
Issued Date
2024-02-07
Resource Type
eISSN
10986596
Scopus ID
2-s2.0-85184521084
Pubmed ID
38193705
Journal Title
Antimicrobial agents and chemotherapy
Volume
68
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antimicrobial agents and chemotherapy Vol.68 No.2 (2024) , e0068423
Suggested Citation
Chery-Karschney L., Patrapuvich R., Mudeppa D.G., Kokkonda S., Chakrabarti R., Sriwichai P., O'Connor R.M., Rathod P.K., White J. Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum. Antimicrobial agents and chemotherapy Vol.68 No.2 (2024) , e0068423. doi:10.1128/aac.00684-23 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97227
Title
Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum
Corresponding Author(s)
Other Contributor(s)
Abstract
Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.