Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti
2
Issued Date
2025-01-01
Resource Type
eISSN
2397334X
Scopus ID
2-s2.0-105002009588
Journal Title
Nature Ecology and Evolution
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Ecology and Evolution (2025)
Suggested Citation
Lozada-Chávez A.N., Lozada-Chávez I., Alfano N., Palatini U., Sogliani D., Elfekih S., Degefa T., Sharakhova M.V., Badolo A., Sriwichai P., Casas-Martínez M., Carlos B.C., Carballar-Lejarazú R., Lambrechts L., Souza-Neto J.A., Bonizzoni M. Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti. Nature Ecology and Evolution (2025). doi:10.1038/s41559-025-02643-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109544
Title
Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti
Author's Affiliation
Université Joseph Ki-Zerbo
Fondazione Human Technopole
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
School of Biosciences
Centro Regional de Investigación en Salud Pública
Jimma University
Rockefeller University
Virginia Tech, Fralin Life Science Institute
Università degli Studi di Pavia
Universität Leipzig
UCI School of Medicine
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Kansas State University
Fondazione Human Technopole
Faculty of Tropical Medicine, Mahidol University
Université Paris Cité
School of Biosciences
Centro Regional de Investigación en Salud Pública
Jimma University
Rockefeller University
Virginia Tech, Fralin Life Science Institute
Università degli Studi di Pavia
Universität Leipzig
UCI School of Medicine
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Kansas State University
Corresponding Author(s)
Other Contributor(s)
Abstract
In the arboviral vector Aedes aegypti, adaptation to anthropogenic environments has led to a major evolutionary shift separating the domestic Aedes aegypti aegypti (Aaa) ecotype from the wild Aedes aegypti formosus (Aaf) ecotype. Aaa mosquitoes are distributed globally and have higher vectorial capacity than Aaf, which remained in Africa. Despite the evolutionary and epidemiological relevance of this separation, inconsistent morphological data and a complex population structure have hindered the identification of genomic signals distinguishing the two ecotypes. Here we assessed the correspondence between the geographic distribution, population structure and genome-wide selection of 511 Aaf and 123 Aaa specimens and report adaptive signals in 186 genes that we call Aaa molecular signatures. Our results indicate that Aaa molecular signatures arose from standing variation associated with extensive ancestral polymorphisms in Aaf populations and have been co-opted for self-domestication through genomic and functional redundancy and local adaptation. Overall, we show that the behavioural shift of Ae. aegypti mosquitoes to live in association with humans relied on the fine regulation of chemosensory, neuronal and metabolic functions, as seen in the domestication processes of rabbits and silkworms. Our results also provide a foundation for the investigation of new genic targets for the control of Ae. aegypti populations.