Genomic Sequencing of Dengue Virus Strains Associated with Papua New Guinean Outbreaks in 2016 Reveals Endemic Circulation of DENV-1 and DENV-2
Issued Date
2022-12-01
Resource Type
ISSN
00029637
eISSN
14761645
Scopus ID
2-s2.0-85144393467
Pubmed ID
35895415
Journal Title
American Journal of Tropical Medicine and Hygiene
Volume
107
Issue
6
Start Page
1234
End Page
1238
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene Vol.107 No.6 (2022) , 1234-1238
Suggested Citation
Jonduo M., Neave M.J., Javati S., Abala D., Bilo E., Kini A., Kumbu J., Laman M., Robinson L.J., Makita L., Susapu M., Pomat W., Abdad M.Y., Williams D.T., Horwood P.F. Genomic Sequencing of Dengue Virus Strains Associated with Papua New Guinean Outbreaks in 2016 Reveals Endemic Circulation of DENV-1 and DENV-2. American Journal of Tropical Medicine and Hygiene Vol.107 No.6 (2022) , 1234-1238. 1238. doi:10.4269/ajtmh.21-1292 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84839
Title
Genomic Sequencing of Dengue Virus Strains Associated with Papua New Guinean Outbreaks in 2016 Reveals Endemic Circulation of DENV-1 and DENV-2
Author's Affiliation
Other Contributor(s)
Abstract
Over the past decade, the Pacific region has experienced many arboviral outbreaks, including dengue, chikungunya, and Zika viruses. Papua New Guinea (PNG) has a high burden of arboviral diseases, but there is a paucity of knowledge about the epidemiology and circulation of these viruses in the country. In this study, we report investigations into suspected arboviral outbreaks of febrile disease in PNG from December 2015 to June 2017. DENV-1 and DENV-2 were the mostly commonly detected viruses, and low circulation of DENV-3 and ZIKV was also detected. DENV-4 and CHIKV were not detected during this period. Full genome sequencing of selected positive samples revealed that circulation was dominated by endemic indigenous strains belonging to DENV-1 (genotype IV) and DENV-2 (genotype C) that have been present in the country for up to a decade. A DENV-2 sublineage was also identified that has been associated with outbreaks of severe dengue in both PNG and the Solomon Islands.