Trends in eczema prevalence in children and adolescents: A Global Asthma Network Phase I Study
Issued Date
2023-03-01
Resource Type
ISSN
09547894
eISSN
13652222
Scopus ID
2-s2.0-85147574596
Journal Title
Clinical and Experimental Allergy
Volume
53
Issue
3
Start Page
337
End Page
352
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and Experimental Allergy Vol.53 No.3 (2023) , 337-352
Suggested Citation
Langan S.M., Mulick A.R., Rutter C.E., Silverwood R.J., Asher I., García-Marcos L., Ellwood E., Bissell K., Chiang C.Y., El-Sony A., Ellwood P., Marks G.B., Mortimer K., Elena Martínez-Torres A., Morales E., Perez-Fernandez V., Robertson S., Williams H.C., Strachan D.P., Pearce N., Asher M.I., Bissell K., Chiang C.Y., El-Sony A., Ellwood E., Ellwood P., García-Marcos L., Marks G.B., Morales E., Mortimer K., Pearce N., Masekela R., Strachan D.P., Perez-Fernández V., Martinez-Torres A., Robertson S., Rutter C.E., Silverwood R.J., Mallol J., Soto-Martinez M.E., Cabrera Aguilar A., Douros K., Mohammed S., Singh M., Singh V., Sukumaran T.U., Awasthi S., Kabra S.K., Salvi S., García-Almaráz R., Mérida-Palacio J.V., Del-Río-Navarro B.E., González-Díaz S.N., Navarrete-Rodriguez E.M., Sánchez J.F., Falade A., Zar H.J., López-Silvarrey Varela A., González Díaz C., Nour M., Dib G., Mohammad Y., Huang J.L., Chinratanapisit S., Soto-Quirós M.E., Vichyanond P., Aguilar P., Barba S., Kumar L., Sharma S.K., Hanumante N.M., Mérida-Palacio J.V., Linares-Zapién F.J., Onadeko B.O., Musa O.A.A., Aguirre V., Baeza-Bacab M., Mohammad S., Cortéz E., Gratziou C.H., Chopra K., Nelson H., Rubio A.D., Hsieh K.H., Shah J. Trends in eczema prevalence in children and adolescents: A Global Asthma Network Phase I Study. Clinical and Experimental Allergy Vol.53 No.3 (2023) , 337-352. 352. doi:10.1111/cea.14276 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113967
Title
Trends in eczema prevalence in children and adolescents: A Global Asthma Network Phase I Study
Author(s)
Langan S.M.
Mulick A.R.
Rutter C.E.
Silverwood R.J.
Asher I.
García-Marcos L.
Ellwood E.
Bissell K.
Chiang C.Y.
El-Sony A.
Ellwood P.
Marks G.B.
Mortimer K.
Elena Martínez-Torres A.
Morales E.
Perez-Fernandez V.
Robertson S.
Williams H.C.
Strachan D.P.
Pearce N.
Asher M.I.
Bissell K.
Chiang C.Y.
El-Sony A.
Ellwood E.
Ellwood P.
García-Marcos L.
Marks G.B.
Morales E.
Mortimer K.
Pearce N.
Masekela R.
Strachan D.P.
Perez-Fernández V.
Martinez-Torres A.
Robertson S.
Rutter C.E.
Silverwood R.J.
Mallol J.
Soto-Martinez M.E.
Cabrera Aguilar A.
Douros K.
Mohammed S.
Singh M.
Singh V.
Sukumaran T.U.
Awasthi S.
Kabra S.K.
Salvi S.
García-Almaráz R.
Mérida-Palacio J.V.
Del-Río-Navarro B.E.
González-Díaz S.N.
Navarrete-Rodriguez E.M.
Sánchez J.F.
Falade A.
Zar H.J.
López-Silvarrey Varela A.
González Díaz C.
Nour M.
Dib G.
Mohammad Y.
Huang J.L.
Chinratanapisit S.
Soto-Quirós M.E.
Vichyanond P.
Aguilar P.
Barba S.
Kumar L.
Sharma S.K.
Hanumante N.M.
Mérida-Palacio J.V.
Linares-Zapién F.J.
Onadeko B.O.
Musa O.A.A.
Aguirre V.
Baeza-Bacab M.
Mohammad S.
Cortéz E.
Gratziou C.H.
Chopra K.
Nelson H.
Rubio A.D.
Hsieh K.H.
Shah J.
Mulick A.R.
Rutter C.E.
Silverwood R.J.
Asher I.
García-Marcos L.
Ellwood E.
Bissell K.
Chiang C.Y.
El-Sony A.
Ellwood P.
Marks G.B.
Mortimer K.
Elena Martínez-Torres A.
Morales E.
Perez-Fernandez V.
Robertson S.
Williams H.C.
Strachan D.P.
Pearce N.
Asher M.I.
Bissell K.
Chiang C.Y.
El-Sony A.
Ellwood E.
Ellwood P.
García-Marcos L.
Marks G.B.
Morales E.
Mortimer K.
Pearce N.
Masekela R.
Strachan D.P.
Perez-Fernández V.
Martinez-Torres A.
Robertson S.
Rutter C.E.
Silverwood R.J.
Mallol J.
Soto-Martinez M.E.
Cabrera Aguilar A.
Douros K.
Mohammed S.
Singh M.
Singh V.
Sukumaran T.U.
Awasthi S.
Kabra S.K.
Salvi S.
García-Almaráz R.
Mérida-Palacio J.V.
Del-Río-Navarro B.E.
González-Díaz S.N.
Navarrete-Rodriguez E.M.
Sánchez J.F.
Falade A.
Zar H.J.
López-Silvarrey Varela A.
González Díaz C.
Nour M.
Dib G.
Mohammad Y.
Huang J.L.
Chinratanapisit S.
Soto-Quirós M.E.
Vichyanond P.
Aguilar P.
Barba S.
Kumar L.
Sharma S.K.
Hanumante N.M.
Mérida-Palacio J.V.
Linares-Zapién F.J.
Onadeko B.O.
Musa O.A.A.
Aguirre V.
Baeza-Bacab M.
Mohammad S.
Cortéz E.
Gratziou C.H.
Chopra K.
Nelson H.
Rubio A.D.
Hsieh K.H.
Shah J.
Author's Affiliation
UNSW Sydney
University of Nottingham
University of Auckland
National and Kapodistrian University of Athens
University of Cape Town
Universidad del Pais Vasco
London School of Hygiene & Tropical Medicine
Mahidol University
All India Institute of Medical Sciences, New Delhi
Chang Gung Memorial Hospital
Chang Gung University
Universidad de Murcia
Postgraduate Institute of Medical Education and Research, Chandigarh
St George’s, University of London
University of Ibadan
South African Medical Research Council
Universidad de Santiago de Chile
UCL Institute of Education
Universidad de Costa Rica
Liverpool School of Tropical Medicine
King George's Medical University
College of Medicine
Hospital Clínico Universitario Virgen de la Arrixaca
Maulana Azad Medical College
Taipei Municipal Wan-Fang Hospital
Universidad Autónoma de Yucatán
Faculty of Medical and Health Sciences
Hospital Infantil de México Federico Gómez
Liverpool University Hospitals NHS Foundation Trust
Department of Medicine
Hospital Universitario Dr. Jose Eleuterio Gonzalez
College of Health Sciences
Universidad Central del Ecuador
International Union Against Tuberculosis and Lung Disease
Chang Gung Children's Hospital
Université Tichrine
Jaslok Hospital and Research Centre
Bharati Vidyapeeth Medical College, Pune
Bhumibol Adulyadej Hospital
National Ribat University
Hospital y CRS El Pino
Chest Research Foundation
Hospital Infantil Manuel de Jesus Rivera
Murcian Bio-Health Institute (IMIB-Arrixaca)
Asthma Bhawan
Research and Development
ARADyAL Allergy Network
Lattakia University
Hospital Infantil de Tamaulipas
Fundación María José Jove
Epidemiological Laboratory for Public Health and Research
Centro De Enfermedades Alergicas Y Asma de Toluca
Centro de Investigacion de Enfermedades Alergicas y Respiratorias
Kothari Medical and Research Institute
AXXIS-Medical Centre SEAICA
PIMS Thiruvalla
ARADyAL Allergy Network
National Center for research and training for chronic respiratory disease and co_morbidities
Horsett Hospital
Pushpagiri Institute of Medical Sciences and Research
IMIB Bio-health Research Institute
Urgencias de Pediatria. Pabellon Makua
ARADyAL Allergy Network
University of Nottingham
University of Auckland
National and Kapodistrian University of Athens
University of Cape Town
Universidad del Pais Vasco
London School of Hygiene & Tropical Medicine
Mahidol University
All India Institute of Medical Sciences, New Delhi
Chang Gung Memorial Hospital
Chang Gung University
Universidad de Murcia
Postgraduate Institute of Medical Education and Research, Chandigarh
St George’s, University of London
University of Ibadan
South African Medical Research Council
Universidad de Santiago de Chile
UCL Institute of Education
Universidad de Costa Rica
Liverpool School of Tropical Medicine
King George's Medical University
College of Medicine
Hospital Clínico Universitario Virgen de la Arrixaca
Maulana Azad Medical College
Taipei Municipal Wan-Fang Hospital
Universidad Autónoma de Yucatán
Faculty of Medical and Health Sciences
Hospital Infantil de México Federico Gómez
Liverpool University Hospitals NHS Foundation Trust
Department of Medicine
Hospital Universitario Dr. Jose Eleuterio Gonzalez
College of Health Sciences
Universidad Central del Ecuador
International Union Against Tuberculosis and Lung Disease
Chang Gung Children's Hospital
Université Tichrine
Jaslok Hospital and Research Centre
Bharati Vidyapeeth Medical College, Pune
Bhumibol Adulyadej Hospital
National Ribat University
Hospital y CRS El Pino
Chest Research Foundation
Hospital Infantil Manuel de Jesus Rivera
Murcian Bio-Health Institute (IMIB-Arrixaca)
Asthma Bhawan
Research and Development
ARADyAL Allergy Network
Lattakia University
Hospital Infantil de Tamaulipas
Fundación María José Jove
Epidemiological Laboratory for Public Health and Research
Centro De Enfermedades Alergicas Y Asma de Toluca
Centro de Investigacion de Enfermedades Alergicas y Respiratorias
Kothari Medical and Research Institute
AXXIS-Medical Centre SEAICA
PIMS Thiruvalla
ARADyAL Allergy Network
National Center for research and training for chronic respiratory disease and co_morbidities
Horsett Hospital
Pushpagiri Institute of Medical Sciences and Research
IMIB Bio-health Research Institute
Urgencias de Pediatria. Pabellon Makua
ARADyAL Allergy Network
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Eczema (atopic dermatitis) is a major global public health issue with high prevalence and morbidity. Our goal was to evaluate eczema prevalence over time, using standardized methodology. Methods: The Global Asthma Network (GAN) Phase I study is an international collaborative study arising from the International Study of Asthma and Allergies in Children (ISAAC). Using surveys, we assessed eczema prevalence, severity, and lifetime prevalence, in global centres participating in GAN Phase I (2015–2020) and one/ both of ISAAC Phase I (1993–1995) and Phase III (2001–2003). We fitted linear mixed models to estimate 10-yearly prevalence trends, by age group, income, and region. Results: We analysed GAN Phase I data from 27 centres in 14 countries involving 74,361 adolescents aged 13–14 and 47,907 children aged 6–7 (response rate 90%, 79%). A median of 6% of children and adolescents had symptoms of current eczema, with 1.1% and 0.6% in adolescents and children, respectively, reporting symptoms of severe eczema. Over 27 years, after adjusting for world region and income, we estimated small overall 10-year increases in current eczema prevalence (adolescents: 0.98%, 95% CI 0.04%–1.92%; children: 1.21%, 95% CI 0.18%–2.24%), and severe eczema (adolescents: 0.26%, 95% CI 0.06%–0.46%; children: 0.23%, 95% CI 0.02%–0.45%) with larger increases in lifetime prevalence (adolescents: 2.71%, 95% CI 1.10%–4.32%; children: 3.91%, 95% CI 2.07%–5.75%). There was substantial heterogeneity in 10-year change between centres (standard deviations 2.40%, 0.58%, and 3.04%), and strong evidence that some of this heterogeneity was explained by region and income level, with increases in some outcomes in high-income children and middle-income adolescents. Conclusions: There is substantial variation in changes in eczema prevalence over time by income and region. Understanding reasons for increases in some regions and decreases in others will help inform prevention strategies.