Effect of endurance exercise on lipid peroxidation product and on scavenging enzymes in short and long distance runners
3
Issued Date
2024
Copyright Date
1993
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xii, 129 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1993
Suggested Citation
Weerasak Ussawawongaraya Effect of endurance exercise on lipid peroxidation product and on scavenging enzymes in short and long distance runners. Thesis (M.Sc. (Physiology))--Mahidol University, 1993. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99337
Title
Effect of endurance exercise on lipid peroxidation product and on scavenging enzymes in short and long distance runners
Alternative Title(s)
ผลของการออกกำลังกายแบบทนทานต่อการเกิดลิปิดเปอร์รอกไซด์และสคาร์ เวนจิงเอ็นไซม์ในนักวิ่งระยะสั้นและระยะไกล
Author(s)
Advisor(s)
Abstract
This study was designed to investigate between the influence of training in short and long distance runners and the effect of endurance exercise on the activities of the scavenging enzymes in erythrocyte such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Plasma malondialdehyde (MDA), LDH and CPK activities were determined as well. Under resting condition, SOD activity was higher (1.4 fold, P<0.05) only in long distance runners than in sedentary subjects but CAT and GSH-Px activities were higher (3 folds and 7.5 folds, respectively, P<0.001) in both short and long distance runners. Each subject was then performed on a bicycle ergometer at 70% of maximum heart rate for 60 minutes. Venous blood were collected before and 5 minutes, 24 and 48 hours after endurance exercise. The enzyme activities were not changed significantly in both short and long distance runners except the reduction of CAT activity as a result of the inactivation by 0(,2). In sedentary subjects, however, SOD, CAT and GSH-Px activities were significantly decreased by about 34.23%, 22.72% and 20.33%, P<0.001, respectively and gradually return to pre-exercise level through the replacement with young erythrocytes which contain higher activities of these enzymes. These results showed that training in short and long distance runners increased the activities of the main free radicals scavenging enzymes in erythrocyte and the influence of endurance exercise inactivated only the CAT activity. Moreover, plasma MDA (index of lipid peroxidation), LDH and CPK actiivities (index of muscle damage) were increased after endurance exercise, with peak values observed at 24 hours (MDA, LDH) and 48 hours (CPK) in these 3 groups. This suggests a possible relationship between free radical generation and exercise-induced muscle damage by less increasing in both short and long distance runners. Thus, a degree of adaptation to training in short and long distance runners might be effective in muscle damage protection.
Description
Physiology (Mahidol University 1993)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University