Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa
Issued Date
2022-05-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85130341355
Pubmed ID
35588422
Journal Title
PLoS ONE
Volume
17
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.17 No.5 (2022)
Suggested Citation
Sueajai J., Sutjarit N., Boonmuen N., Auparakkitanon S., Noumjad N., Suksamrarn A., Vinayavekhin N., Piyachaturawat P.V.P. Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa. PLoS ONE Vol.17 No.5 (2022). doi:10.1371/journal.pone.0268179 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86518
Title
Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa
Other Contributor(s)
Abstract
Decline of ovarian function in menopausal women increases metabolic disease risk. Curcuma comosa extract and its major compound, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD), improved estrogen-deficient ovariectomized (OVX) rat metabolic disturbances. However, information on their effects on metabolites is limited. Here, we investigated the impacts of C. comosa ethanol extract and DPHD on 12-week-old OVX rat metabolic disturbances, emphasizing the less hydrophobic metabolites. Metabolomics analysis of OVX rat serum showed a marked increase compared to sham-operated rat (SHAM) in levels of lysophosphatidylcholines (lysoPCs), particularly lysoPC (18:0) and lysoPC (16:0), and of arachidonic acid (AA), metabolites associated with inflammation. OVX rat elevated lysoPCs and AA levels reverted to SHAM levels following treatments with C. comosa ethanol extract and DPHD. Overall, our studies demonstrate the effect of C. comosa extract in ameliorating the metabolic disturbances caused by ovariectomy, and the elevated levels of bioactive lipid metabolites, lysoPCs and AA, may serve as potential biomarkers of menopausal metabolic disturbances.