Comparative genome analysis of Streptococcus suis serotype 5 strains from humans and pigs revealed pathogenic potential of virulent, antimicrobial resistance, and genetic relationship
Issued Date
2023-01-01
Resource Type
ISSN
12864579
eISSN
1769714X
Scopus ID
2-s2.0-85179916429
Pubmed ID
38070594
Journal Title
Microbes and Infection
Rights Holder(s)
SCOPUS
Bibliographic Citation
Microbes and Infection (2023)
Suggested Citation
Kerdsin A., Hatrongjit R., Wongsurawat T., Jenjaroenpun P., Zheng H., Chopjitt P., Boueroy P., Fittipaldi N., Segura M., Gottschalk M. Comparative genome analysis of Streptococcus suis serotype 5 strains from humans and pigs revealed pathogenic potential of virulent, antimicrobial resistance, and genetic relationship. Microbes and Infection (2023). doi:10.1016/j.micinf.2023.105273 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95853
Title
Comparative genome analysis of Streptococcus suis serotype 5 strains from humans and pigs revealed pathogenic potential of virulent, antimicrobial resistance, and genetic relationship
Corresponding Author(s)
Other Contributor(s)
Abstract
Streptococcus suis is a causative agent of swine and human infections. Genomic analysis indicated that eight S. suis serotype 5 strains recovered from human patients and pigs carried many virulence-associated genes and markers defining pathogenic pathotypes. The strains were sequence types diverse and clustered within either minimum core genome group 3 (MCG-3) or MCG-7-3. Almost all the serotype 5 strains were non-susceptible to penicillin, ceftriaxone, erythromycin, and levofloxacin. Resistance to tetracycline and clindamycin was observed in all strains. The antimicrobial resistance genes tet(O), tet(O/W/32/O), tet(W), tet(44), erm(B), ant(6)-Ia, lsaE, and lnuB were found in these strains. Moderate-to-large numbers of substitutions were observed in three penicillin-binding proteins (PBP)—PBP1A, PBP2B, and PBP2X—in the penicillin-non-susceptible serotype 5 isolates that were involved in β-lactam-non-susceptibility. Comparative genomics between the serotype 5 and 2 strains revealed that only 15 genes absent from the serotype 2 strains were shared by all the serotype 5 strains. However, some additional genes were present only in some of the serotype 5 strains. This study highlighted the pathogenic potential of virulent serotype 5 strains in humans and pigs and the need for increased monitoring of penicillin-non-susceptibility in S. suis serotypes other than for serotype 2.