A nationwide mixed-methods study of gaps and barriers to implementation of antimicrobial stewardship programmes in hospitals in Indonesia
Issued Date
2024-12-01
Resource Type
ISSN
01956701
eISSN
15322939
Scopus ID
2-s2.0-85208473412
Pubmed ID
39426628
Journal Title
Journal of Hospital Infection
Volume
154
Start Page
77
End Page
87
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Hospital Infection Vol.154 (2024) , 77-87
Suggested Citation
Sinto R., Limato R., Radiani S.P., Huda M.N., Surendra H., Praptiwi A.W., Herman Y., Musaffa B.A., Lazarus G., Day N.P.J., Limmathurotsakul D., Karuniawati A., Hamers R.L. A nationwide mixed-methods study of gaps and barriers to implementation of antimicrobial stewardship programmes in hospitals in Indonesia. Journal of Hospital Infection Vol.154 (2024) , 77-87. 87. doi:10.1016/j.jhin.2024.10.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102011
Title
A nationwide mixed-methods study of gaps and barriers to implementation of antimicrobial stewardship programmes in hospitals in Indonesia
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: There is an urgent need to understand the implementation barriers of antimicrobial stewardship programmes (ASPs) in low- and middle-income countries. Methods: We conducted a mixed-methods study in public and private hospitals across all provinces in Indonesia (March–December 2023). We used a self-assessment questionnaire with a scoring system, and multi-level ordinal regression to assess associations with hospital and district-level characteristics. Focus group discussions (FGDs) with hospital stakeholders examined barriers and enablers. We applied a patient safety framework to integrate results. Results: A total of 575 (19%) of 3026 hospitals completed the self-assessment, of whom 516 (89.7%) had a formal ASP (median 4 (interquartile range (IQR) 1–5] years), and 14 participated in FGD. The median overall ASP development score was 48.4% (35.9–62.5%), classifying 41 (8.0%) hospitals as inadequate (0–25%), 237 (45.9%) as basic (26–50%), 179 (34.7%) as intermediate (51–75%) and 59 (11.4%) as advanced (76–100%). Scores were highest for hospital leadership support (83.4% (IQR 66.7–100%)), followed by ASP team and infectious disease training (66.7% (IQR 55.6–77.8%)); education (50% (IQR 0.0–75.0%)); ASP interventions (43.8% (IQR 18.7–68.7%)); hospital infrastructure (42.9% (IQR 14.3–71.4%)); and monitoring, reporting and feedback (40.9% (IQR 27.3–54.5%)). A higher ASP development score was associated with higher hospital tiered level, longer ASP duration, and higher district-level Public Health Development Index and per capita domestic expenditure, but not with hospital ownership or geographic region. FGDs highlighted barriers related to hospital leadership support, staff technical and behavioural skills, cross-disciplinary collaboration, fear of loss of prescriber autonomy, microbiology and IT support, and hospital accreditation. Conclusions: Identified implementation barriers can inform actions for context-specific, sustainable improvement of ASPs.