Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart’s Disease
Issued Date
2023-03-01
Resource Type
ISSN
16616596
eISSN
14220067
Scopus ID
2-s2.0-85151107895
Pubmed ID
36982732
Journal Title
International Journal of Molecular Sciences
Volume
24
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences Vol.24 No.6 (2023)
Suggested Citation
Chaemsaithong P., Luewan S., Taweevisit M., Chiangjong W., Pongchaikul P., Thorner P.S., Tongsong T., Chutipongtanate S. Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart’s Disease. International Journal of Molecular Sciences Vol.24 No.6 (2023). doi:10.3390/ijms24065658 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81631
Title
Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart’s Disease
Author's Affiliation
Ramathibodi Hospital
Faculty of Medicine, Chiang Mai University
King Chulalongkorn Memorial Hospital
University of Liverpool
University of Cincinnati College of Medicine
University of Toronto
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Faculty of Medicine, Chulalongkorn University
Faculty of Medicine, Chiang Mai University
King Chulalongkorn Memorial Hospital
University of Liverpool
University of Cincinnati College of Medicine
University of Toronto
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Faculty of Medicine, Chulalongkorn University
Other Contributor(s)
Abstract
Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into extracellular fluids and specifically contain signature molecules of the original cells and tissues, including the placenta. Placenta-derived EVs can be detected in maternal circulation at as early as six weeks of gestation, and their release can be triggered by the oxygen level and glucose concentration. Placental-associated complications such as preeclampsia, fetal growth restriction, and gestational diabetes have alterations in placenta-derived EVs in maternal plasma, and this can be used as a liquid biopsy for the diagnosis, prediction, and monitoring of such pregnancy complications. Alpha-thalassemia major (“homozygous alpha-thalassemia-1”) or hemoglobin Bart’s disease is the most severe form of thalassemia disease, and this condition is lethal for the fetus. Women with Bart’s hydrops fetalis demonstrate signs of placental hypoxia and placentomegaly, thereby placenta-derived EVs provide an opportunity for a non-invasive liquid biopsy of this lethal condition. In this article, we introduced clinical features and current diagnostic markers of Bart’s hydrops fetalis, extensively summarize the characteristics and biology of placenta-derived EVs, and discuss the challenges and opportunities of placenta-derived EVs as part of diagnostic tests for placental complications focusing on Bart’s hydrop fetalis.
