The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study
Issued Date
2022-01-01
Resource Type
ISSN
19454589
Scopus ID
2-s2.0-85125001311
Pubmed ID
35100136
Journal Title
Aging
Volume
14
Issue
3
Start Page
1087
End Page
1099
Rights Holder(s)
SCOPUS
Bibliographic Citation
Aging Vol.14 No.3 (2022) , 1087-1099
Suggested Citation
Hol L., Oosten P.V., Nijbroek S., Tsonas A., Botta M., Neto A.S., Paulus F., Schultz M. The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study. Aging Vol.14 No.3 (2022) , 1087-1099. 1099. doi:10.18632/aging.203863 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83926
Title
The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study
Other Contributor(s)
Abstract
Introduction: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID–19 patients requiring invasive ventilation. Methods: Posthoc analysis of the PRoVENT–COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end–expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital– and ICU stay, and mortality. Results: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality. Conclusions: In this cohort of invasively ventilated critically ill COVID–19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.