High PrEP uptake, adherence, persistence and effectiveness outcomes among young Thai men and transgender women who sell sex in Bangkok and Pattaya, Thailand: findings from the open-label combination HIV prevention effectiveness (COPE) study
Issued Date
2023-08-01
Resource Type
eISSN
27723682
Scopus ID
2-s2.0-85162890881
Journal Title
The Lancet Regional Health - Southeast Asia
Volume
15
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Lancet Regional Health - Southeast Asia Vol.15 (2023)
Suggested Citation
Weir B.W., Wirtz A.L., Chemnasiri T., Baral S.D., Decker M., Dun C., Hnin Mon S.H., Ungsedhapand C., Dunne E.F., Woodring J., Pattanasin S., Sukwicha W., Thigpen M.C., Varangrat A., Warapornmongkholkul A., O'Connor S., Ngo J.P., Qaragholi N., Sisel H.I., Truong J.M., Janyam S., Linjongrat D., Sriplienchan S., Sirivongrangson P., Rooney J.F., Sullivan P., Chua-Intra B., Hickey A.C., Beyrer C., Wirtz A., Weir B., Baral S., Case J., Truong J.M., Ngo J.P., Sisel H.I., Chitwarakorn A., Matsee W., Wongkiti P., Krasan C., Chainuwong A., Imlimtharn N., Reansoi P., Watanatanyaporn T., Nuamlert J., Namwong S., Phetnark J., Supasa W., Sueayot S., Hickey A.C., Thigpen M.C., Dunne E.F., Vu C., Flaherty P., Holtz T., Chanthaweesirirat A., Thienkrua W., Disprayoon P., Kamkong K., Worrajittanon D., Na-Pompet S., Sariwatta C., Oungprasertgul P., Sittidech P., Suksamosorn J., Sujina K., Chonwattana W., Kamchaithep N., Tatakham N., Luechai P., Mock P., Cadwell B., Shrestha R., Balmongkol B., Raengsakulrach B., Leelawiwat W., Suwannaphan W., Sriinsut A., Wasinrapee P., Chanathalay P., Promda N., Winaitham S., Kongpechsatit O., Auethavornanan K., Tongtoyai J., Tararut P., McNamara A., Mueanpai F., Sakulploy N., Pancharoen K., Utenpitak C., Fukuda C., Cherdtrakulkiat T., Janthiraj T., Sriporn A., Prathummart N., Khongsom P., Navanuch N., Wongbenchaporn R., Peerapatdit C. High PrEP uptake, adherence, persistence and effectiveness outcomes among young Thai men and transgender women who sell sex in Bangkok and Pattaya, Thailand: findings from the open-label combination HIV prevention effectiveness (COPE) study. The Lancet Regional Health - Southeast Asia Vol.15 (2023). doi:10.1016/j.lansea.2023.100217 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87789
Title
High PrEP uptake, adherence, persistence and effectiveness outcomes among young Thai men and transgender women who sell sex in Bangkok and Pattaya, Thailand: findings from the open-label combination HIV prevention effectiveness (COPE) study
Author(s)
Weir B.W.
Wirtz A.L.
Chemnasiri T.
Baral S.D.
Decker M.
Dun C.
Hnin Mon S.H.
Ungsedhapand C.
Dunne E.F.
Woodring J.
Pattanasin S.
Sukwicha W.
Thigpen M.C.
Varangrat A.
Warapornmongkholkul A.
O'Connor S.
Ngo J.P.
Qaragholi N.
Sisel H.I.
Truong J.M.
Janyam S.
Linjongrat D.
Sriplienchan S.
Sirivongrangson P.
Rooney J.F.
Sullivan P.
Chua-Intra B.
Hickey A.C.
Beyrer C.
Wirtz A.
Weir B.
Baral S.
Case J.
Truong J.M.
Ngo J.P.
Sisel H.I.
Chitwarakorn A.
Matsee W.
Wongkiti P.
Krasan C.
Chainuwong A.
Imlimtharn N.
Reansoi P.
Watanatanyaporn T.
Nuamlert J.
Namwong S.
Phetnark J.
Supasa W.
Sueayot S.
Hickey A.C.
Thigpen M.C.
Dunne E.F.
Vu C.
Flaherty P.
Holtz T.
Chanthaweesirirat A.
Thienkrua W.
Disprayoon P.
Kamkong K.
Worrajittanon D.
Na-Pompet S.
Sariwatta C.
Oungprasertgul P.
Sittidech P.
Suksamosorn J.
Sujina K.
Chonwattana W.
Kamchaithep N.
Tatakham N.
Luechai P.
Mock P.
Cadwell B.
Shrestha R.
Balmongkol B.
Raengsakulrach B.
Leelawiwat W.
Suwannaphan W.
Sriinsut A.
Wasinrapee P.
Chanathalay P.
Promda N.
Winaitham S.
Kongpechsatit O.
Auethavornanan K.
Tongtoyai J.
Tararut P.
McNamara A.
Mueanpai F.
Sakulploy N.
Pancharoen K.
Utenpitak C.
Fukuda C.
Cherdtrakulkiat T.
Janthiraj T.
Sriporn A.
Prathummart N.
Khongsom P.
Navanuch N.
Wongbenchaporn R.
Peerapatdit C.
Wirtz A.L.
Chemnasiri T.
Baral S.D.
Decker M.
Dun C.
Hnin Mon S.H.
Ungsedhapand C.
Dunne E.F.
Woodring J.
Pattanasin S.
Sukwicha W.
Thigpen M.C.
Varangrat A.
Warapornmongkholkul A.
O'Connor S.
Ngo J.P.
Qaragholi N.
Sisel H.I.
Truong J.M.
Janyam S.
Linjongrat D.
Sriplienchan S.
Sirivongrangson P.
Rooney J.F.
Sullivan P.
Chua-Intra B.
Hickey A.C.
Beyrer C.
Wirtz A.
Weir B.
Baral S.
Case J.
Truong J.M.
Ngo J.P.
Sisel H.I.
Chitwarakorn A.
Matsee W.
Wongkiti P.
Krasan C.
Chainuwong A.
Imlimtharn N.
Reansoi P.
Watanatanyaporn T.
Nuamlert J.
Namwong S.
Phetnark J.
Supasa W.
Sueayot S.
Hickey A.C.
Thigpen M.C.
Dunne E.F.
Vu C.
Flaherty P.
Holtz T.
Chanthaweesirirat A.
Thienkrua W.
Disprayoon P.
Kamkong K.
Worrajittanon D.
Na-Pompet S.
Sariwatta C.
Oungprasertgul P.
Sittidech P.
Suksamosorn J.
Sujina K.
Chonwattana W.
Kamchaithep N.
Tatakham N.
Luechai P.
Mock P.
Cadwell B.
Shrestha R.
Balmongkol B.
Raengsakulrach B.
Leelawiwat W.
Suwannaphan W.
Sriinsut A.
Wasinrapee P.
Chanathalay P.
Promda N.
Winaitham S.
Kongpechsatit O.
Auethavornanan K.
Tongtoyai J.
Tararut P.
McNamara A.
Mueanpai F.
Sakulploy N.
Pancharoen K.
Utenpitak C.
Fukuda C.
Cherdtrakulkiat T.
Janthiraj T.
Sriporn A.
Prathummart N.
Khongsom P.
Navanuch N.
Wongbenchaporn R.
Peerapatdit C.
Author's Affiliation
Rollins School of Public Health
Centers for Disease Control and Prevention
Centers for Disease Control (CDC), Thailand Field Station
Duke University
Johns Hopkins Bloomberg School of Public Health
Gilead Sciences Incorporated
Service Workers in Group Foundation (SWING)
Rainbow Sky Association of Thailand
Centers for Disease Control and Prevention
Centers for Disease Control (CDC), Thailand Field Station
Duke University
Johns Hopkins Bloomberg School of Public Health
Gilead Sciences Incorporated
Service Workers in Group Foundation (SWING)
Rainbow Sky Association of Thailand
Other Contributor(s)
Abstract
Background: Daily oral pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection, but no study has evaluated combination prevention interventions with PrEP for transgender women (TGW) and men who have sex with men (MSM) who sell sex. Methods: The Combination Prevention Effectiveness (COPE) study was a community-based, non-randomized implementation study in Bangkok and Pattaya, Thailand. Participants were HIV-negative MSM and TGW aged 18–26 years who reported exchanging sex with men in the prior 12 months and who met 2014 U.S. Public Health Service PrEP eligibility criteria. The intervention included quarterly HIV testing, semiannual testing for sexually transmitted infections, provision of condoms with lubricant, and the opportunity to initiate or end daily oral PrEP use at any time during study participation. Participants taking PrEP received monthly adherence counseling and short message service reminders. The primary outcome was HIV incidence rate ratio (IRR) on PrEP vs. not on PrEP. Secondary outcomes were PrEP initiation, PrEP use at 12 months, and PrEP adherence. Findings: From October 2017 to August 2019, 846 participants were enrolled: 531 (62.8%) immediately initiated PrEP; 104 (12.3%) subsequently initiated PrEP, and 211 (24.9%) never initiated PrEP. Among those initiating PrEP within 30 days of enrollment; 85.9% were on PrEP at the 12-months. When taking PrEP, participants reported adherent PrEP use at 94.2% of quarterly assessments. Ten HIV seroconversions occurred without PrEP use (incidence rate [IR] = 3.42 per 100 person-years [PY]; 95% CI = 1.64–6.30), while zero cases occurred with PrEP use (IR = 0.0 per 100PY; 95% CI = 0.0–0.62), with IRR = 0.0 (95% CI = 0.0–0.22; p < 0.001). Interpretation: Young Thai MSM and TGW who exchange sex can have high PrEP uptake, persistence and adherence, and low HIV incidence when offered in supportive community-based settings. Funding: U.S. National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention.