Storage Duration and Red Blood Cell-Derived Microparticles in Packed Red Blood Cells Obtained from Donors with Thalassemia
Issued Date
2022-05-01
Resource Type
ISSN
00075027
eISSN
19437730
Scopus ID
2-s2.0-85125197804
Pubmed ID
34791365
Journal Title
Lab Medicine
Volume
53
Issue
3
Start Page
302
End Page
306
Rights Holder(s)
SCOPUS
Bibliographic Citation
Lab Medicine Vol.53 No.3 (2022) , 302-306
Suggested Citation
Noulsri E., Lerdwana S., Palasuwan D., Palasuwan A. Storage Duration and Red Blood Cell-Derived Microparticles in Packed Red Blood Cells Obtained from Donors with Thalassemia. Lab Medicine Vol.53 No.3 (2022) , 302-306. 306. doi:10.1093/labmed/lmab106 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87321
Title
Storage Duration and Red Blood Cell-Derived Microparticles in Packed Red Blood Cells Obtained from Donors with Thalassemia
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To address the effects of storage duration on red blood cell (RBC)-derived microparticles (RMPs) in packed RBCs from donors who have thalassemia. Materials and Methods: Packed RBCs were prepared according to laboratory routine. The quantity of RMPs was determined using FACSCalibur and counting beads. Results: Across durations of storage, the packed RBCs from donors with thalassemia (n = 28) and healthy volunteers (n = 104) showed average RMPs to be 47,426 (10,139 127,785) particles/μL vs 49,021 (13,033 126,749) particles/μL, respectively (P =. 63). The peak RMP levels in donors with thalassemia and healthy volunteers, respectively, were shown in products from storage days 34 and 38. Both groups showed a trend toward a positive association between RMP concentration and the duration of storage in packed RBC bags stored under blood bank conditions. Conclusion: Our results suggest that storage-induced RMP release has similar effects in stored packed RBCs obtained from both donors with thalassemia and healthy volunteers.