Effect of low-dose dexmedetomidine to prolong spinal anesthesia in elderly patients: a prospective randomized controlled study
Issued Date
2024-12-01
Resource Type
eISSN
14712253
Scopus ID
2-s2.0-85210441815
Journal Title
BMC Anesthesiology
Volume
24
Issue
1
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SCOPUS
Bibliographic Citation
BMC Anesthesiology Vol.24 No.1 (2024)
Suggested Citation
Sangkum L., Termpornlert S., Tunprasit C., Rathanasutthajohn C., Komonhirun R., Dusitkasem S. Effect of low-dose dexmedetomidine to prolong spinal anesthesia in elderly patients: a prospective randomized controlled study. BMC Anesthesiology Vol.24 No.1 (2024). doi:10.1186/s12871-024-02815-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102314
Title
Effect of low-dose dexmedetomidine to prolong spinal anesthesia in elderly patients: a prospective randomized controlled study
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Abstract
Background: Spinal anesthesia for transurethral resection of the prostate (TURP) has a short duration, which poses challenges for postoperative pain management. The present study aimed to investigate the effects of intravenous (IV) dexmedetomidine at a dosage of 0.4 µg/kg in prolonging the duration of spinal anesthesia and minimizing postoperative pain in elderly patients undergoing TURP. Methods: This prospective randomized controlled trial enrolled 38 patients aged 60–80 years who underwent elective TURP with spinal anesthesia. The patients were randomly assigned to two treatment groups: Group D received IV 0.4 µg/kg dexmedetomidine, whereas Group C received IV normal saline after spinal anesthesia administration. The primary outcome was the time to 2-dermatome regression. Results: The 2-dermatome regression time was longer in Group D than in Group C (104.44 ± 16.97 min vs. 80.63 ± 15.59 min, p < 0.05). The peak sensory block levels were significantly higher in Group D [T7 (T6–T8)] than in Group C [T10 (T7–T10)] (p = 0.017). The incidence of hypotension and bradycardia and postoperative pain at 0, 6, 12, and 24 h were not different between two groups. Conclusion: Intravenous dexmedetomidine at a dosage of 0.4 µg/kg significantly prolongs the duration of spinal sensory blockade. Although postoperative analgesia was not different, it provided hemodynamic stability without increasing the side effects.