The evolving role of mast cells in wound healing: insights from recent research and diverse models
Issued Date
2024-01-01
Resource Type
ISSN
08189641
eISSN
14401711
Scopus ID
2-s2.0-85205918217
Journal Title
Immunology and Cell Biology
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SCOPUS
Bibliographic Citation
Immunology and Cell Biology (2024)
Suggested Citation
Guth C., Limjunyawong N., Pundir P. The evolving role of mast cells in wound healing: insights from recent research and diverse models. Immunology and Cell Biology (2024). doi:10.1111/imcb.12824 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101605
Title
The evolving role of mast cells in wound healing: insights from recent research and diverse models
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Abstract
Chronic wounds significantly burden health care systems worldwide, requiring novel strategies to ease their impact. Many physiological processes underlying wound healing are well studied but the role of mast cells remains controversial. Mast cells are innate immune cells and play an essential role in barrier function by inducing inflammation to defend the host against chemical irritants and infections, among others. Many mast cell–derived mediators have proposed roles in wound healing; however, in vivo evidence using mouse models has produced conflicting results. Recently, studies involving more complex wound models such as infected wounds, diabetic wounds and wounds healing under psychological stress suggest that mast cells play critical roles in these processes. This review briefly summarizes the existing literature regarding mast cells in normal wounds and the potential reasons for the contradictory results. Focus will be placed on examining more recent work emerging in the last 5 years that explores mast cells in more complex systems of wound healing, including infection, psychological stress and diabetes, with a discussion of how these discoveries may inspire future work in the field.