Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials
Issued Date
2022-09-01
Resource Type
eISSN
20796382
Scopus ID
2-s2.0-85138514417
Journal Title
Antibiotics
Volume
11
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antibiotics Vol.11 No.9 (2022)
Suggested Citation
Sulaiman M., Jannat K., Nissapatorn V., Rahmatullah M., Paul A.K., de Lourdes Pereira M., Rajagopal M., Suleiman M., Butler M.S., Break M.K.B., Weber J.F., Wilairatana P., Wiart C. Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials. Antibiotics Vol.11 No.9 (2022). doi:10.3390/antibiotics11091146 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83614
Title
Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials
Author's Affiliation
Other Contributor(s)
Abstract
The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å2, and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2′-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC ≤ 1 µg/mL and are candidates for the development of lead molecules.
