Cardiovascular and metabolic outcomes associated with moderate-to-severe atopic dermatitis: A systematic review and meta-analysis
Issued Date
2025-03-01
Resource Type
eISSN
19394551
Scopus ID
2-s2.0-85218868620
Journal Title
World Allergy Organization Journal
Volume
18
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
World Allergy Organization Journal Vol.18 No.3 (2025)
Suggested Citation
Untaaveesup S., Amnartpanich T., Jirattikanwong N., Boonsom A., Treemethawee T., Srichana P., Yimkijboriharn C., Phinyo P., Laisuan W., Thongngarm T. Cardiovascular and metabolic outcomes associated with moderate-to-severe atopic dermatitis: A systematic review and meta-analysis. World Allergy Organization Journal Vol.18 No.3 (2025). doi:10.1016/j.waojou.2025.101035 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/105546
Title
Cardiovascular and metabolic outcomes associated with moderate-to-severe atopic dermatitis: A systematic review and meta-analysis
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Chronic systemic inflammation in individuals with moderate-to-severe atopic dermatitis (AD) potentially predisposes them to metabolic and cardiovascular diseases. Nevertheless, evidence with regard to such association is limited. Objective: To assess the association between metabolic and cardiovascular outcomes and moderate-to-severe AD. Methods: A systematic search was performed through PubMed, Scopus, EMBASE, and Cochrane for population-based studies that addressed the effects of moderate-to-severe AD on metabolic and cardiovascular outcomes compared with the general population from inception to August 31, 2023. Meta-analysis was performed using the random effects model. The pooled odds ratio (OR) and certainty of evidence for each outcome were reported. Results: We included 11 studies, 4 retrospective cohorts, 1 prospective cohort, 4 cross-sectional, and 2 case-control studies involving 405,170 moderate-to-severe AD patients compared to 4,591,478 unaffected controls. Moderate-to-severe AD was associated with a higher risk of myocardial infarction with an OR (95% CI) of 1.33 (1.07, 1.65), angina 1.33 (1.06, 1.66), heart failure 1.56 (1.28, 1.90), stroke 1.45 (1.21, 1.74), hypertension 1.38 (1.18, 1.63), dyslipidemia 1.27 (1.15, 1.41), and metabolic syndrome 1.24 (1.05, 1.42) with very low certainty of evidence. No significantly increased risk of cardiovascular death with an odds ratio (95% CI) of 1.81 (0.96, 3.44) and diabetes of 1.24 (0.91, 1.68) was observed. High heterogeneity was observed in most studies for all of the outcomes. Conclusion: Our meta-analysis demonstrated a modest but significant association between moderate-to-severe AD and increased susceptibility to metabolic and cardiovascular diseases. Initial assessment of cardiovascular and metabolic risk for patients with moderate-to-severe AD should be considered to enable early management strategies.