Factors associated with false-negative for T-SPOT.TB in patients with TB disease
Issued Date
2023-02-01
Resource Type
eISSN
18157920
Scopus ID
2-s2.0-85149154029
Pubmed ID
36853117
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Volume
27
Issue
2
Start Page
128
End Page
134
Rights Holder(s)
SCOPUS
Bibliographic Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Vol.27 No.2 (2023) , 128-134
Suggested Citation
Tochaeng C., Eksombatchai D., Boonsarngsuk V. Factors associated with false-negative for T-SPOT.TB in patients with TB disease. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Vol.27 No.2 (2023) , 128-134. 134. doi:10.5588/ijtld.22.0368 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82403
Title
Factors associated with false-negative for T-SPOT.TB in patients with TB disease
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
BACKGROUND:: T-SPOT.TB is an adjunctive diagnostic tool that is used for detecting TB disease. However, in some patients with TB disease, a false-negative result can occur. This study aims to determine the factors that are associated with false-negative T-SPOT.TB results in TB disease.METHODS:: We retrospectively enrolled 210 patients who were diagnosed with TB disease and underwent T-SPOT.TB testing between July 2014 and July 2020 at Ramathibodi Hospital Bangkok, Thailand. Clinical characteristics, laboratory findings and radiographic findings were compared between the false-negative and true-positive T-SPOT.TB groups.RESULTS:: Among 210 patients with TB disease, 144 patients had pulmonary TB, 44 patients had extrapulmonary TB and 22 patients had concomitant pulmonary and extrapulmonary TB. There were 100 male and 110 female patients, with a mean age of 54.1 ± 17.5 years. Ninety patients (42.9%) had false-negative T-SPOT.TB results. Multivariate analysis showed that increased age was significantly associated with false-negative T-SPOT.TB (OR 1.025, 95% CI 1.008-1.043, P = 0.006). Those aged ≥55 years had 1.8 times higher false-negative T-SPOT.TB rate than the younger group (age ≥55 years: 64.4% vs. age <55 years: 35.6%; P = 0.001).CONCLUSION:: Advanced age, particularly age ≥55 years, was a significant factor that related with false-negative T-SPOT.TB results in TB disease.