Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus)
Issued Date
2024-01-01
Resource Type
ISSN
09167250
eISSN
13477439
Scopus ID
2-s2.0-85181910887
Pubmed ID
37940547
Journal Title
Journal of Veterinary Medical Science
Volume
86
Issue
1
Start Page
49
End Page
53
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Veterinary Medical Science Vol.86 No.1 (2024) , 49-53
Suggested Citation
Kawaguchi N., Fuke N., Nueangphuet P., Pornthummawat A., Niazi A.M., Izzati U.Z., Hirai T., Yamaguchi R. Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus). Journal of Veterinary Medical Science Vol.86 No.1 (2024) , 49-53. 53. doi:10.1292/jvms.23-0152 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95985
Title
Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus)
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Corresponding Author(s)
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Abstract
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.