Different ventilation intensities among various categories of patients ventilated for reasons other than ARDS––A pooled analysis of 4 observational studies
Issued Date
2024-06-01
Resource Type
ISSN
08839441
eISSN
15578615
Scopus ID
2-s2.0-85185485854
Pubmed ID
38341938
Journal Title
Journal of Critical Care
Volume
81
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Critical Care Vol.81 (2024)
Suggested Citation
Serafini S.C., van Meenen D.M.P., Pisani L., Neto A.S., Ball L., de Abreu M.G., Algera A.G., Azevedo L., Bellani G., Dondorp A.M., Fan E., Laffey J.G., Pham T., Tschernko E.M., Schultz M.J., van der Woude M.C.E. Different ventilation intensities among various categories of patients ventilated for reasons other than ARDS––A pooled analysis of 4 observational studies. Journal of Critical Care Vol.81 (2024). doi:10.1016/j.jcrc.2024.154531 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97396
Title
Different ventilation intensities among various categories of patients ventilated for reasons other than ARDS––A pooled analysis of 4 observational studies
Author's Affiliation
Institute of Health Policy, Management and Evaluation
Mahidol Oxford Tropical Medicine Research Unit
Melbourne Medical School
IRCCS San Martino Polyclinic Hospital
Université Paris-Saclay
Ospedale S. Chiara
University Hospital Galway
Università degli Studi di Genova
Cleveland Clinic Foundation
Hospital Israelita Albert Einstein
Università di Trento
Hopital de Bicetre
Faculty of Medicine, Nursing and Health Sciences
Medizinische Universität Wien
Nuffield Department of Medicine
Universidade de São Paulo
Amsterdam UMC - University of Amsterdam
Miulli Regional Hospital
Doctors with Africa CUAMM
Mahidol Oxford Tropical Medicine Research Unit
Melbourne Medical School
IRCCS San Martino Polyclinic Hospital
Université Paris-Saclay
Ospedale S. Chiara
University Hospital Galway
Università degli Studi di Genova
Cleveland Clinic Foundation
Hospital Israelita Albert Einstein
Università di Trento
Hopital de Bicetre
Faculty of Medicine, Nursing and Health Sciences
Medizinische Universität Wien
Nuffield Department of Medicine
Universidade de São Paulo
Amsterdam UMC - University of Amsterdam
Miulli Regional Hospital
Doctors with Africa CUAMM
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose: We investigated driving pressure (ΔP) and mechanical power (MP) and associations with clinical outcomes in critically ill patients ventilated for reasons other than ARDS. Materials and methods: Individual patient data analysis of a pooled database that included patients from four observational studies of ventilation. ΔP and MP were compared among invasively ventilated non–ARDS patients with sepsis, with pneumonia, and not having sepsis or pneumonia. The primary endpoint was ΔP; secondary endpoints included MP, ICU mortality and length of stay, and duration of ventilation. Results: This analysis included 372 (11%) sepsis patients, 944 (28%) pneumonia patients, and 2040 (61%) patients ventilated for any other reason. On day 1, median ΔP was higher in sepsis (14 [11-18] cmH2O) and pneumonia patients (14 [11-18]cmH2O), as compared to patients not having sepsis or pneumonia (13 [10-16] cmH2O) (P < 0.001). Median MP was also higher in sepsis and pneumonia patients. ΔP, as opposed to MP, was associated with ICU mortality in sepsis and pneumonia patients. Conclusions: The intensity of ventilation differed between patients with sepsis or pneumonia and patients receiving ventilation for any other reason; ΔP was associated with higher mortality in sepsis and pneumonia patients. Registration: This post hoc analysis was not registered; the individual studies that were merged into the used database were registered at clinicaltrials.gov: NCT01268410 (ERICC), NCT02010073 (LUNG SAFE), NCT01868321 (PRoVENT), and NCT03188770 (PRoVENT–iMiC).