Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes
Issued Date
2022-01-01
Resource Type
eISSN
11769343
Scopus ID
2-s2.0-85134665671
Journal Title
Evolutionary Bioinformatics
Volume
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
Evolutionary Bioinformatics Vol.18 (2022)
Suggested Citation
Pholtaisong J., Chaiyaratana N., Aporntewan C., Mutirangura A. Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes. Evolutionary Bioinformatics Vol.18 (2022). doi:10.1177/11769343221110656 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83367
Title
Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes
Other Contributor(s)
Abstract
Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus. Principal Findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes. Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.