Tight junctions: from molecules to gastrointestinal diseases
Issued Date
2023-01-01
Resource Type
ISSN
21688362
eISSN
21688370
Scopus ID
2-s2.0-85131159245
Pubmed ID
35621376
Journal Title
Tissue Barriers
Volume
11
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tissue Barriers Vol.11 No.2 (2023)
Suggested Citation
Moonwiriyakit A., Pathomthongtaweechai N., Steinhagen P.R., Chantawichitwong P., Satianrapapong W., Pongkorpsakol P. Tight junctions: from molecules to gastrointestinal diseases. Tissue Barriers Vol.11 No.2 (2023). doi:10.1080/21688370.2022.2077620 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83491
Title
Tight junctions: from molecules to gastrointestinal diseases
Other Contributor(s)
Abstract
Intestinal epithelium functions as a tissue barrier to prevent interaction between the internal compartment and the external milieu. Intestinal barrier function also determines epithelial polarity for the absorption of nutrients and the secretion of waste products. These vital functions require strong integrity of tight junction proteins. In fact, intestinal tight junctions that seal the paracellular space can restrict mucosal-to-serosal transport of hostile luminal contents. Tight junctions can form both an absolute barrier and a paracellular ion channel. Although defective tight junctions potentially lead to compromised intestinal barrier and the development and progression of gastrointestinal (GI) diseases, no FDA-approved therapies that recover the epithelial tight junction barrier are currently available in clinical practice. Here, we discuss the impacts and regulatory mechanisms of tight junction disruption in the gut and related diseases. We also provide an overview of potential therapeutic targets to restore the epithelial tight junction barrier in the GI tract.