The first complete genome sequence of the Streptomyces boninensis TBRC 7755 type strain provides a promising source of bioactive compounds

Abstract

The Streptomyces genus is a remarkable source of bioactive compounds in the pharmaceutical repertoire of nature. Here, we present the first complete genome sequence of Streptomyces boninensis TBRC 7755 assembled using a hybrid sequencing approach combining Illumina and PacBio technologies. The genome comprises a high-quality 9.6-Mb linear chromosome, exhibiting exceptionally high completeness and minimal contamination. Phylogenomic analysis and genomic relatedness metrics of S. coryli A7024 provide reliable reference data for comparative genomic studies. The genome architecture revealed 8543 protein-coding genes complemented by a diverse RNA repertoire comprising 15 rRNAs, 60 tRNAs, and 3 ncRNAs. Genome mining identified biosynthetic gene clusters encoding potentially bioactive compounds, including the iron-chelating siderophore desferrioxamine, antineoplastic peptide chaxapeptin, and antimicrobial griseobactin. These computational predictions require experimental validation to confirm bioactivity. This genomic blueprint serves two purposes: (1) providing reference data for bacterial taxonomy and (2) illuminating pathways for the discovery of potential bioactive compounds.