Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis
Issued Date
2022-12-16
Resource Type
ISSN
00257974
eISSN
15365964
Scopus ID
2-s2.0-85144543842
Pubmed ID
36550893
Journal Title
Medicine (United States)
Volume
101
Issue
50
Rights Holder(s)
SCOPUS
Bibliographic Citation
Medicine (United States) Vol.101 No.50 (2022)
Suggested Citation
Boongird C., Tearneukit W., Wongpipathpong W., McKay G.J., Thakkinstian A. Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis. Medicine (United States) Vol.101 No.50 (2022). doi:10.1097/MD.0000000000032382 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85164
Title
Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis
Author's Affiliation
Other Contributor(s)
Abstract
Background: Alzheimer disease (AD) is the most common cause of dementia worldwide. Despite the publication of numerous systematic reviews and meta-analyses that have summarized the evidence associated with pharmacotherapies (PTs) and non-pharmacotherapies (NPTs) for the wide range of interventions available for AD treatment, their comparative safety and efficacy remains insufficiently defined. Methods: Systematic reviews of randomized controlled trials (RCTs) will be selected according to the following criteria: conducted in elderly patients aged 60 years or older with AD living in community or institutionalized settings, applied pairwise meta-analysis (PMA) or network meta-analysis (NMA) approaches providing pooled relative treatment effects for at least 1 pair of PTs or NPTs, and providing at least 1 of the following outcomes for patients/caregivers: cognitive, functional status, behavior, quality of life (QoL), and caregiver stress or burden. All article screening, data extraction, and risk of bias assessment will be completed independently by 2 reviewers. Relative treatment rankings will be reported with mean ranks and surface under the cumulative ranking curves. Results and Conclusion: We will determine the most efficacious treatment strategies for AD patients from the most highly ranked treatments. These results will help to guide clinical decision-making and improve patient care.