Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys
Issued Date
2023-10-03
Resource Type
eISSN
14620332
Scopus ID
2-s2.0-85173572236
Pubmed ID
36734536
Journal Title
Rheumatology (Oxford, England)
Volume
62
Issue
10
Start Page
3291
End Page
3301
Rights Holder(s)
SCOPUS
Bibliographic Citation
Rheumatology (Oxford, England) Vol.62 No.10 (2023) , 3291-3301
Suggested Citation
Sen P., Naveen R., Houshmand N., Moghadam Kia S., Joshi M., Saha S., Jagtap K., Agarwal V., Nune A., Nikiphorou E., Tan A.L., Shinjo S.K., Ziade N., Velikova T., Milchert M., Parodis I., Gracia-Ramos A.E., Cavagna L., Kuwana M., Knitza J., Makol A., Patel A., Pauling J.D., Wincup C., Barman B., Zamora Tehozol E.A., Rojas Serrano J., García-De La Torre I., Colunga-Pedraza I.J., Merayo-Chalico J., Chibuzo O.C., Katchamart W., Akawatcharangura Goo P., Shumnalieva R., Chen Y.M., Hoff L.S., El Kibbi L., Halabi H., Vaidya B., Sazliyana Shaharir S., Hasan A.T.M.T., Dey D., GutiCrossed D Sign©rrez C.E.T., Caballero-Uribe C.V., Lilleker J.B., Salim B., Gheita T., Chatterjee T., Distler O., Saavedra M.A., Day J., Chinoy H., Kardes S., Andreoli L., Lini D., Screiber K., Vince M.N., Singh Y.P., Ranjan R., Jain A., Pandya S.C., Pilania R.K., Sharma A., Manesh Manoj M., Gupta V., Kavadichanda C.G., Patro P.S., Ajmani S., Phatak S., Goswami R.P., Chowdhury A.C., Mathew A.J., Shenoy P., Asranna A., Bommakanti K.T., Shukla A., Pande A.R., Chandwar K., Ghodke A., Boro H., Fazal Z.Z., Cansu D.Ü., Ylldlrlm R., Gasparyan A.Y., Del Papa N., Sambataro G., Fabiola A., Govoni M., Parisi S., Bocci E.B., Sebastiani G.D., Fusaro E., Sebastiani M., Quartuccio L., Franceschini F., Sainaghi P.P., Orsolini G., De Angelis R., Danielli M.G., Venerito V. Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys. Rheumatology (Oxford, England) Vol.62 No.10 (2023) , 3291-3301. 3301. doi:10.1093/rheumatology/kead057 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90665
Title
Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys
Author(s)
Sen P.
Naveen R.
Houshmand N.
Moghadam Kia S.
Joshi M.
Saha S.
Jagtap K.
Agarwal V.
Nune A.
Nikiphorou E.
Tan A.L.
Shinjo S.K.
Ziade N.
Velikova T.
Milchert M.
Parodis I.
Gracia-Ramos A.E.
Cavagna L.
Kuwana M.
Knitza J.
Makol A.
Patel A.
Pauling J.D.
Wincup C.
Barman B.
Zamora Tehozol E.A.
Rojas Serrano J.
García-De La Torre I.
Colunga-Pedraza I.J.
Merayo-Chalico J.
Chibuzo O.C.
Katchamart W.
Akawatcharangura Goo P.
Shumnalieva R.
Chen Y.M.
Hoff L.S.
El Kibbi L.
Halabi H.
Vaidya B.
Sazliyana Shaharir S.
Hasan A.T.M.T.
Dey D.
GutiCrossed D Sign©rrez C.E.T.
Caballero-Uribe C.V.
Lilleker J.B.
Salim B.
Gheita T.
Chatterjee T.
Distler O.
Saavedra M.A.
Day J.
Chinoy H.
Kardes S.
Andreoli L.
Lini D.
Screiber K.
Vince M.N.
Singh Y.P.
Ranjan R.
Jain A.
Pandya S.C.
Pilania R.K.
Sharma A.
Manesh Manoj M.
Gupta V.
Kavadichanda C.G.
Patro P.S.
Ajmani S.
Phatak S.
Goswami R.P.
Chowdhury A.C.
Mathew A.J.
Shenoy P.
Asranna A.
Bommakanti K.T.
Shukla A.
Pande A.R.
Chandwar K.
Ghodke A.
Boro H.
Fazal Z.Z.
Cansu D.Ü.
Ylldlrlm R.
Gasparyan A.Y.
Del Papa N.
Sambataro G.
Fabiola A.
Govoni M.
Parisi S.
Bocci E.B.
Sebastiani G.D.
Fusaro E.
Sebastiani M.
Quartuccio L.
Franceschini F.
Sainaghi P.P.
Orsolini G.
De Angelis R.
Danielli M.G.
Venerito V.
Naveen R.
Houshmand N.
Moghadam Kia S.
Joshi M.
Saha S.
Jagtap K.
Agarwal V.
Nune A.
Nikiphorou E.
Tan A.L.
Shinjo S.K.
Ziade N.
Velikova T.
Milchert M.
Parodis I.
Gracia-Ramos A.E.
Cavagna L.
Kuwana M.
Knitza J.
Makol A.
Patel A.
Pauling J.D.
Wincup C.
Barman B.
Zamora Tehozol E.A.
Rojas Serrano J.
García-De La Torre I.
Colunga-Pedraza I.J.
Merayo-Chalico J.
Chibuzo O.C.
Katchamart W.
Akawatcharangura Goo P.
Shumnalieva R.
Chen Y.M.
Hoff L.S.
El Kibbi L.
Halabi H.
Vaidya B.
Sazliyana Shaharir S.
Hasan A.T.M.T.
Dey D.
GutiCrossed D Sign©rrez C.E.T.
Caballero-Uribe C.V.
Lilleker J.B.
Salim B.
Gheita T.
Chatterjee T.
Distler O.
Saavedra M.A.
Day J.
Chinoy H.
Kardes S.
Andreoli L.
Lini D.
Screiber K.
Vince M.N.
Singh Y.P.
Ranjan R.
Jain A.
Pandya S.C.
Pilania R.K.
Sharma A.
Manesh Manoj M.
Gupta V.
Kavadichanda C.G.
Patro P.S.
Ajmani S.
Phatak S.
Goswami R.P.
Chowdhury A.C.
Mathew A.J.
Shenoy P.
Asranna A.
Bommakanti K.T.
Shukla A.
Pande A.R.
Chandwar K.
Ghodke A.
Boro H.
Fazal Z.Z.
Cansu D.Ü.
Ylldlrlm R.
Gasparyan A.Y.
Del Papa N.
Sambataro G.
Fabiola A.
Govoni M.
Parisi S.
Bocci E.B.
Sebastiani G.D.
Fusaro E.
Sebastiani M.
Quartuccio L.
Franceschini F.
Sainaghi P.P.
Orsolini G.
De Angelis R.
Danielli M.G.
Venerito V.
Author's Affiliation
Faculty of Medicine and Health
Siriraj Hospital
UCL Division of Medicine
Graduate School of Medicine
Bristol Medical School
NIHR Leeds Biomedical Research Centre
Southport and Ormskirk Hospital NHS Trust
Manchester University NHS Foundation Trust
Health Innovation Manchester
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Fauji Foundation Hospital
Hospital General de Occidente
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Universidad del Norte
Ministry of Health and Family Welfare
University of Nevada, Las Vegas
University of Virginia School of Medicine
Sveti Ivan Rilski hospital
Universitätsklinikum Erlangen
Universidade Potiguar
North Bristol NHS Trust
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
University of Nigeria
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Faculty of Medicine
University of Leeds, School of Medicine
University of Illinois College of Medicine
University College London
Mymensingh Medical College
King's College Hospital
Sofia University St. Kliment Ohridski
UniversitatsSpital Zurich
Karolinska Universitetssjukhuset
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI
Pomeranian Medical University in Szczecin
Hospital Universitario Dr. Jose Eleuterio Gonzalez
University of Ghana
King Faisal Specialist Hospital and Research Centre
Università degli Studi di Pavia
King's College London
Maulana Azad Medical College
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Instituto Mexicano del Seguro Social
Instituto Nacional de Enfermedades Respiratorias
Universidade de São Paulo
Birmingham City Hospital
The Royal Wolverhampton NHS Trust
Veterans General Hospital-Taichung Taiwan
Mayo Clinic
Royal Melbourne Hospital
Salford Royal Hospital
University of Pittsburgh School of Medicine
Faculty of Medicine, UKM
Queen Savang Vadhana Memorial Hospital
National Center for Rheumatic Diseases
Specialized Medical Center Hospital
Enam Medical College and Hospital
Mahatma Gandhi Mission Medical College
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
Siriraj Hospital
UCL Division of Medicine
Graduate School of Medicine
Bristol Medical School
NIHR Leeds Biomedical Research Centre
Southport and Ormskirk Hospital NHS Trust
Manchester University NHS Foundation Trust
Health Innovation Manchester
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Fauji Foundation Hospital
Hospital General de Occidente
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Universidad del Norte
Ministry of Health and Family Welfare
University of Nevada, Las Vegas
University of Virginia School of Medicine
Sveti Ivan Rilski hospital
Universitätsklinikum Erlangen
Universidade Potiguar
North Bristol NHS Trust
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
University of Nigeria
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Faculty of Medicine
University of Leeds, School of Medicine
University of Illinois College of Medicine
University College London
Mymensingh Medical College
King's College Hospital
Sofia University St. Kliment Ohridski
UniversitatsSpital Zurich
Karolinska Universitetssjukhuset
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI
Pomeranian Medical University in Szczecin
Hospital Universitario Dr. Jose Eleuterio Gonzalez
University of Ghana
King Faisal Specialist Hospital and Research Centre
Università degli Studi di Pavia
King's College London
Maulana Azad Medical College
Instituto Nacional de la Nutrición Salvador Zubiran
Salford Royal NHS Foundation Trust
Instituto Mexicano del Seguro Social
Instituto Nacional de Enfermedades Respiratorias
Universidade de São Paulo
Birmingham City Hospital
The Royal Wolverhampton NHS Trust
Veterans General Hospital-Taichung Taiwan
Mayo Clinic
Royal Melbourne Hospital
Salford Royal Hospital
University of Pittsburgh School of Medicine
Faculty of Medicine, UKM
Queen Savang Vadhana Memorial Hospital
National Center for Rheumatic Diseases
Specialized Medical Center Hospital
Enam Medical College and Hospital
Mahatma Gandhi Mission Medical College
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
Other Contributor(s)
Abstract
OBJECTIVE: COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. METHODS: The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. RESULTS: We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. CONCLUSION: Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.