Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia
1
Issued Date
2025-01-01
Resource Type
ISSN
10570829
eISSN
1536481X
Scopus ID
2-s2.0-105009708517
Pubmed ID
40536831
Journal Title
Journal of Glaucoma
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Glaucoma (2025)
Suggested Citation
Jiravarnsirikul A., Belghith A., Rezapour J., Micheletti E., Nishida T., Moghimi S., Suh M.H., Jonas J.B., Walker E., Christopher M., Fazio M.A., Weinreb R.N., Zangwill L.M. Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia. Journal of Glaucoma (2025). doi:10.1097/IJG.0000000000002606 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111172
Title
Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose: To evaluate the relationship between a juxtapapillary choriocapillaris microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with or without axial myopia. Methods: This cross-sectional study included 125 patients with POAG or glaucoma suspects stratified into no axial myopia (axial length (AL) < 24 mm; 46 eyes), mild axial myopia (24 mm< AL < 26 mm; 81 eyes), and high axial myopia (AL > 26 mm; 59 eyes). Presence, area, and angular circumference of juxtapapillary MvD were evaluated on OCT-A en-face choroidal images and B-scans. Perimetry was conducted using the 24-2C and 10-2 Humphrey program. Results: Mean 24-2C VF mean deviation was significantly worse in eyes with MvD compared to eyes without MvD across all groups (all p<0.042). Central VF defects detected in the 24-2C and 10-2 VF tests were significantly more prevalent among eyes with MvD (68.3% and 81.7%, respectively) compared to eyes without MvD (19.0% and 38.1%, respectively) (p < 0.001) in the mild axial myopia group. In multivariable analysis, larger MvD area (p=0.014) and wider MvD angular circumference (p=0.006) were significantly associated with higher likelihood of the presence of 24-2C central VF damage in overall cohort. Conclusions: MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia. Choriocapillaris MvD assessment shows promise for identifying POAG patients with a higher risk of having central VF defects and may provide clinical insights into the pathogenesis of glaucoma in myopia.