A data-driven model to estimate breathing-induced intra-trunk blood shifts during exercise
Issued Date
2025-06-01
Resource Type
ISSN
87507587
eISSN
15221601
Scopus ID
2-s2.0-105008323317
Journal Title
Journal of Applied Physiology
Volume
138
Issue
6
Start Page
1581
End Page
1599
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Applied Physiology Vol.138 No.6 (2025) , 1581-1599
Suggested Citation
Corigliano G., Uva B., Kayser B., Aliverti A., Stucky F. A data-driven model to estimate breathing-induced intra-trunk blood shifts during exercise. Journal of Applied Physiology Vol.138 No.6 (2025) , 1581-1599. 1599. doi:10.1152/japplphysiol.00749.2024 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110858
Title
A data-driven model to estimate breathing-induced intra-trunk blood shifts during exercise
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Author's Affiliation
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Abstract
The pressure swings generated by the respiratory muscles induce blood shifts (Vbs) between the trunk and the extremities. Vbs varies with swing amplitude and breathing pattern and can reach sizable volumes. Although Vbs was successfully explored using double-body plethysmography, the extent of intra-trunk blood shifting (between abdomen and thorax, Vbs<inf>IT</inf>) remains to be quantified. We here present an electrical model of the cardiovascular system that allows to derive quantitative estimates of breath-by-breath Vbs<inf>IT</inf>. We first validated the model with experimental data collected from healthy participants performing exercise with various breathing patterns, including spontaneous (CTRL), abdominal (AB), and rib cage breathing (RC), and with external expiratory flow limitation (EFLe). We then fed the model with other experimental data to derive Vbs<inf>IT</inf> in a proof-of-concept fashion. Breath-by-breath fluctuations in Vbs derived from the model matched experimental data. Computations of Vbs<inf>IT</inf> were in line with expectations, showing small fluctuations with spontaneous breathing and substantial increases during AB, RC, and EFLe. Intrabreath Vbs<inf>IT</inf> showed a close relationship with intra-breath transdiaphragmatic pressure during inspiration in all conditions and during expiration in AB and RC, reflecting the net effect of hydraulic pressure fluctuations on blood displacement between the two compartments. This model may benefit further work investigating (patho)physiological mechanisms of various conditions affecting cardiorespiratory function, both at rest and during exercise.