Anti-inflammatory activity of verbascoside- and isoverbascoside-rich Lamiales medicinal plants
Issued Date
2024-01-15
Resource Type
ISSN
24058440
Scopus ID
2-s2.0-85180320748
Journal Title
Heliyon
Volume
10
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heliyon Vol.10 No.1 (2024)
Suggested Citation
Pongkitwitoon B., Putalun W., Triwitayakorn K., Kitisripanya T., Kanchanapoom T., Boonsnongcheep P. Anti-inflammatory activity of verbascoside- and isoverbascoside-rich Lamiales medicinal plants. Heliyon Vol.10 No.1 (2024). doi:10.1016/j.heliyon.2023.e23644 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95923
Title
Anti-inflammatory activity of verbascoside- and isoverbascoside-rich Lamiales medicinal plants
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Verbascoside and isoverbascoside are two active phenylethanoid glycosides mainly found in plants of the order Lamiales. This study analyzes the verbascoside and isoverbascoside levels and the total phenolic contents in the water and ethanolic extracts of 20 medicinal plants of the order Lamiales commonly used in Thailand. The related bioactivities, including the antioxidant activity via the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reduction activity potential assays and anti-tyrosinase and -inflammatory activities via the cyclooxygenase and nitric oxide assays are also investigated. The extracts of several plant species, including Barleria prionitis, B. lupulina, Rhinacanthus nasutus, Orthosiphon aristatus, and Nicoteba betonica, exhibit high verbascoside and isoverbascoside content levels. The correlation analysis between the bioactive activities and the active compounds demonstrates a significant association between the verbascoside level in the water extracts and both the DPPH antioxidant activity and the nitric oxide level in the anti-inflammatory assays. This study provides the first report on the verbascoside and isoverbascoside quantification of several plant samples. The findings provide valuable insights for future research on lesser-studied plants possessing high verbascoside and isoverbascoside levels, which exhibit promising anti-inflammatory activities.