Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria
Issued Date
2026-04-01
Resource Type
eISSN
20457022
Scopus ID
2-s2.0-105036015501
Journal Title
Clinical and Translational Allergy
Volume
16
Issue
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and Translational Allergy Vol.16 No.4 (2026)
Suggested Citation
Soetanto K.M., Sripatumtong C., Paringkarn T., Angkoolpakdeekul N., Kulthanan K., Srinoulprasert Y. Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria. Clinical and Translational Allergy Vol.16 No.4 (2026). doi:10.1002/clt2.70168 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116417
Title
Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria
Author's Affiliation
Corresponding Author(s)
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Abstract
Background: Chronic Spontaneous Urticaria (CSU) is a debilitating skin condition characterized by recurrent wheals and pruritus, significantly impacting quality of life. Molecular mechanisms underlying different severity phenotypes are not fully understood. This study aimed to investigate the expression of FCER1A and PTAFR genes in basophils implicated in CSU pathogenesis from CSU patients with varying disease severities. Methods: We recruited 45 CSU patients, stratified into mild (n = 15), moderate (n = 15), and severe (n = 15) groups, and 15 healthy controls. Basophils were isolated from peripheral blood, and the relative mRNA expression of FCER1A and PTAFR genes was quantified using real-time PCR. Results: CSU patients exhibited significantly higher expression levels of FCER1A and PTAFR genes compared to healthy controls. FCER1A expression was significantly elevated in all CSU groups compared to controls and was higher in moderate and severe groups than in the mild group. PAFR expression was also significantly higher in moderate and severe CSU. Correlation analysis revealed that both FCER1A and PTAFR mRNA expression levels positively correlate with CSU severity. Conclusion: The expression of FCER1A and PTAFR genes in basophils correlates significantly with CSU severity, suggesting their potential as both prognostic and severity biomarkers. These findings highlight key molecular pathways that could be targeted for therapeutic intervention. Early detection of elevated gene expression could facilitate timely, targeted treatments, potentially reducing the progression to severe disease in CSU patients.