Trimethylamine-N-oxide and 5-year mortality: the role of gut microbiota-generated metabolite from the CORE-Thailand cohort

Senthong V.; Kiatchoosakun S.; Wongvipaporn C.; Phetcharaburanin J.; Sritara P.; Phrommintikul A.; Worasuwannarak S.; Dutsadeevettakul S.; Suksuphew S.; Cheewatanakornkul S.; Suwanugsorn S.; Taweesangsuksakul P.; Tatsanaviva P.; Simtharakaew T.; Sukanandachai B.; Dinchuthai P.; Kositchaiwat J.; Siriaree K.; Siriwattana K.; Chotechuang Y.; Phengtham U.; Watcharasaksilp K.; Buranapin S.; Prasertwitayakij N.; Wongcharoen W.; Paspitsanu P.; Laksomya T.; Maraprasertsak M.; Jai-aue S.; Wongtheptien W.; Deerochanawong C.; Hutayanon P.; Changsirikulchai S.; Porapakkham P.; Kanaderm C.; Suraamornkul S.; Satirapoj B.; Tiyanon W.; Rattanasumawong K.; Wongpraparut N.; Boonyasirinant T.; Krittayaphong R.; Udol K.; Lertsuwunseri V.; Satitthummanid S.; Boonyaratavej S.; Srimahachota S.; Yamwong S.

Trimethylamine-N-oxide and 5-year mortality: the role of gut microbiota-generated metabolite from the CORE-Thailand cohort

Issued Date

2024-12-01

Resource Type

Article

eISSN

20452322

DOI

10.1038/s41598-024-71479-z

Scopus ID

2-s2.0-85203683604

Journal Title

Scientific Reports

Volume

14

Issue

1

Rights Holder(s)

SCOPUS

Bibliographic Citation

Scientific Reports Vol.14 No.1 (2024)

Suggested Citation

Senthong V., Kiatchoosakun S., Wongvipaporn C., Phetcharaburanin J., Sritara P., Phrommintikul A., Worasuwannarak S., Dutsadeevettakul S., Suksuphew S., Cheewatanakornkul S., Suwanugsorn S., Taweesangsuksakul P., Senthong V., Tatsanaviva P., Kiatchoosakun S., Wongvipaporn C., Simtharakaew T., Sukanandachai B., Dinchuthai P., Kositchaiwat J., Siriaree K., Siriwattana K., Chotechuang Y., Phengtham U., Watcharasaksilp K., Buranapin S., Prasertwitayakij N., Wongcharoen W., Phrommintikul A., Paspitsanu P., Laksomya T., Maraprasertsak M., Jai-aue S., Wongtheptien W., Deerochanawong C., Hutayanon P., Changsirikulchai S., Porapakkham P., Kanaderm C., Suraamornkul S., Satirapoj B., Tiyanon W., Rattanasumawong K., Wongpraparut N., Boonyasirinant T., Krittayaphong R., Udol K., Lertsuwunseri V., Satitthummanid S., Boonyaratavej S., Srimahachota S., Yamwong S., Sritara P. Trimethylamine-N-oxide and 5-year mortality: the role of gut microbiota-generated metabolite from the CORE-Thailand cohort. Scientific Reports Vol.14 No.1 (2024). doi:10.1038/s41598-024-71479-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101266

Title

Trimethylamine-N-oxide and 5-year mortality: the role of gut microbiota-generated metabolite from the CORE-Thailand cohort

Corresponding Author(s)

Senthong V.

Other Contributor(s)

Mahidol University

Abstract

The gut microbiota metabolite trimethylamine-N-oxide (TMAO)—derived from dietary phosphatidylcholine—is mechanistically linked to cardiovascular disease (CVD) and increased cardiovascular risk. This study examined the relationship between fasting plasma TMAO levels and 5-year all-cause mortality in a cohort of patients at high risk of cardiovascular events (CORE-Thailand Registry). Of the 134 patients, 123 (92%) had established cardiovascular disease, and 11 (8%) had multiple risk factors. Fasting plasma TMAO levels were measured using nuclear magnetic resonance spectroscopy. Within this prospective cohort study, the median TMAO was 3.81 μM [interquartile range (IQR) 2.89–5.50 μM], with a mean age of 65 ± 11 years; 61% were men, and 39.6% had type II diabetes. Among 134 patients, 65 (49%) were identified as the high-TMAO group (≥ 3.8 μM), and 69 (51%) were identified as the low-TMAO group (< 3.8 μM). After a median follow-up of 58.8 months, the high-TMAO group was associated with a 2.88-fold increased mortality risk. Following adjustment for traditional risk factors, high-sensitivity cardiac troponin-T, estimated glomerular filtration rate, angiotensin-converting enzyme (ACEI), or angiotensin-receptor blocker (ARB) use, the high-TMAO group remained predictive of 5-year all-cause mortality risk (the high-TMAO vs. the low-TMAO group, adjusted hazard ratio 2.73, 95% CI 1.13–6.54; P = 0.025). Among Thai patients at high risk of cardiovascular events, increased plasma TMAO levels portended greater long-term mortality risk.

Keyword(s)

Multidisciplinary

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/101266

Collections

Scopus 2024

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