Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways
Issued Date
2026-01-01
Resource Type
ISSN
13510002
eISSN
17432928
Scopus ID
2-s2.0-105030632692
Pubmed ID
41715893
Journal Title
Redox Report
Volume
31
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Redox Report Vol.31 No.1 (2026)
Suggested Citation
Maunjumpon P., Thamsermsang O., Panich U. Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways. Redox Report Vol.31 No.1 (2026). doi:10.1080/13510002.2026.2629079 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115433
Title
Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways
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Author's Affiliation
Corresponding Author(s)
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Abstract
Exposure to fine particulate matter smaller than 2.5 μm in diameter (PM2.5) has emerged as a critical environmental factor contributing to skin injury. As the skin is the body’s primary barrier against the external environment, it is directly susceptible to PM2.5, which induces oxidative stress, inflammation, premature aging, and disruption of skin barrier function. Increasing evidence demonstrates that PM2.5 damages both epidermal keratinocytes and dermal fibroblasts, leading to cellular dysfunction through alterations in major signaling pathways, including the aryl hydrocarbon receptor (AhR), nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), mitogen-activated protein kinase (MAPK), and nuclear factor erythroid 2–related factor 2 (Nrf2). These molecular perturbations accelerate skin aging and impair protective functions, highlighting the need for effective intervention strategies. Botanicals and their bioactive phytochemicals have attracted growing interest for their antioxidant and anti-inflammatory properties, which may counteract PM2.5-induced damage. By targeting redox imbalance and inflammatory signaling, natural compounds represent a promising approach for protecting skin health. This review highlights the role of PM2.5 in skin injury and critically examines botanical strategies that may mitigate PM2.5-induced skin damage and premature aging.