A pure compound from Curcuma comosa Roxb. protects neurons against hydrogen peroxide-induced neurotoxicity via the activation of Nrf-2
Issued Date
2022-11-01
Resource Type
ISSN
24058440
Scopus ID
2-s2.0-85141999414
Journal Title
Heliyon
Volume
8
Issue
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heliyon Vol.8 No.11 (2022)
Suggested Citation
Khin Aung Z.M., Jantaratnotai N., Piyachaturawat P., Sanvarinda P. A pure compound from Curcuma comosa Roxb. protects neurons against hydrogen peroxide-induced neurotoxicity via the activation of Nrf-2. Heliyon Vol.8 No.11 (2022). doi:10.1016/j.heliyon.2022.e11228 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86460
Title
A pure compound from Curcuma comosa Roxb. protects neurons against hydrogen peroxide-induced neurotoxicity via the activation of Nrf-2
Author's Affiliation
Other Contributor(s)
Abstract
Oxidative stress plays a pivotal role in several human diseases including Parkinson's disease (PD). Curcuma comosa, a member of Zingiberaceae, is widely known in Thailand as an alternative medicinal herb for uterine inflammation and estrogenic properties. In this study (3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol or compound 092 (C-092, or ASPP 092), a pure compound isolated from ethanol extract of C. comosa, was evaluated for neuroprotective effect on hydrogen peroxide-induced toxicity in SH-SY5Y cells. C-092 demonstrated a radical scavenging effect with comparable efficacy to ascorbic acid and exhibited a neuroprotective effect via suppression of apoptotic cell death as evidenced by a reduction in phospho-p53 and cleaved caspase-3 expression. C-092 causes induction of Nrf-2, which is a transcription factor responsible for the expression of a range of antioxidant genes. Moreover, the reduction in catalase activity caused by hydrogen peroxide was also alleviated by C-092 treatment. These results suggested the therapeutic potential of this compound for neurodegenerative diseases caused by oxidative stress.