Tacca chantrieri (Andre) Crude Extract Promoted Immunity in the Elderly (Ex-Vivo), and Inhibited Pathogenic and Opportunistic Bacteria
Issued Date
2026-01-01
Resource Type
eISSN
2515690X
Scopus ID
2-s2.0-105028250171
Pubmed ID
41575914
Journal Title
Journal of Evidence Based Integrative Medicine
Volume
31
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Evidence Based Integrative Medicine Vol.31 (2026)
Suggested Citation
Chatsakulphanit C., Phanthanawiboon S., Thanee M., Salao K., Tippayawat P., Leelayuwat C., Chuangchot N., Sirichoat A., Nithichanon A., Kamsom C., Papalee S., Chuenchom C., Phoksawat W. Tacca chantrieri (Andre) Crude Extract Promoted Immunity in the Elderly (Ex-Vivo), and Inhibited Pathogenic and Opportunistic Bacteria. Journal of Evidence Based Integrative Medicine Vol.31 (2026). doi:10.1177/2515690X261418404 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114606
Title
Tacca chantrieri (Andre) Crude Extract Promoted Immunity in the Elderly (Ex-Vivo), and Inhibited Pathogenic and Opportunistic Bacteria
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Tacca chantrieri (Andre), or the black bat flower, is commonly found in Southeast Asia; however, its effects on immunity have not been studied. This study aimed to investigate the effects of T. chantrieri crude extract on CD4+ T cell phenotypes and on the phagocytosis and oxidative burst of polymorphonuclear neutrophils (PMNs) in the elderly (ex-vivo). Its ability to inhibit opportunistic and pathogenic bacteria was also evaluated. Methods: T chantrieri crude extract was obtained by ethanolic extraction. A total of eight elderly (age ≥65 years) were enrolled in the study. Investigations used flow cytometric analysis. Antimicrobial effects were explored by agar well diffusion and minimum inhibition concentration (MIC) testing. Results: CD4+ T cell proportion significantly decreased at the 100 μg/ml concentration (p = 0.015). CD4+NKG2D+ T cells decreased at all concentrations (50, 100, 200, 300 μg/ml). Regarding PMNs, phagocytosis and oxidative burst in the treated group were significantly increased at 15 min compared with the untreated group (p = 0.039 and 0.015, respectively). Regarding antimicrobial effect, 100 mg/ml crude extract inhibited Staphylococcus epidermidis, Staphylococcus aureus, Neisseria sicca, and Acinetobacter lwoffii. MIC values were 1.23, 3.70, 33.33, and 100 mg/ml, respectively. Conclusions: This work reports preliminary findings of immunity promotion in the elderly following treatment with T. chantrieri crude extract. In future, the extract may be developed into a natural herb product or a form of alternative medicine for immune status enhancement, as well as a potential antimicrobial agent, particularly in the elderly.