Postural abnormalities in Asian and Caucasian Parkinson's disease patients: A multicenter study
Issued Date
2022-04-01
Resource Type
ISSN
13538020
eISSN
18735126
Scopus ID
2-s2.0-85127190226
Pubmed ID
35378428
Journal Title
Parkinsonism and Related Disorders
Volume
97
Start Page
91
End Page
98
Rights Holder(s)
SCOPUS
Bibliographic Citation
Parkinsonism and Related Disorders Vol.97 (2022) , 91-98
Suggested Citation
Pongmala C. Postural abnormalities in Asian and Caucasian Parkinson's disease patients: A multicenter study. Parkinsonism and Related Disorders Vol.97 (2022) , 91-98. 98. doi:10.1016/j.parkreldis.2022.03.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86718
Title
Postural abnormalities in Asian and Caucasian Parkinson's disease patients: A multicenter study
Author(s)
Author's Affiliation
Siriraj Hospital
King Fahad Medical City
CHU de Toulouse
Gyeongsang National University
Faculdade de Medicina, Universidade de Lisboa
Samsung Medical Center, Sungkyunkwan university
SKKU School of Medicine
Università degli Studi di Torino
Universitätsklinikum Schleswig-Holstein Campus Kiel
Instituto Medicina Molecular João Lobo Antunes
CNS—Campus Neurológico
King Fahad Medical City
CHU de Toulouse
Gyeongsang National University
Faculdade de Medicina, Universidade de Lisboa
Samsung Medical Center, Sungkyunkwan university
SKKU School of Medicine
Università degli Studi di Torino
Universitätsklinikum Schleswig-Holstein Campus Kiel
Instituto Medicina Molecular João Lobo Antunes
CNS—Campus Neurológico
Other Contributor(s)
Abstract
Introduction: Postural abnormalities (PA) are disabling features of Parkinson's disease (PD). Indirect analyses suggested a higher prevalence of PA among Asian patients compared to Caucasian ones, but no direct comparisons have been performed so far. Methods: An international, multicenter, cross-sectional study was performed in 6 European and Asian movement disorders centers with the aim to clarify differences and similarities of prevalence and characteristics of PA in Asian vs. Caucasian PD patients. Axial PA, encompassing antecollis (AC), camptocormia (CC), and Pisa syndrome (PS), and appendicular PA (appPA) were systematically searched and analysed in consecutive patients. Results: 88 (27%) of 326 PD patients had PA (29.1% in Asians and 24.3% in Caucasians, p: 0.331). Prevalence of axial PA was 23.6% in Asians and 24.3% in Caucasians (p = 0.886), in spite of a longer disease duration among Caucasians, but a longer PA duration among Asians. No differences in prevalence between AC, CC, and PS were found between the two ethnicities. The prevalence of appPA was higher in Asians (p = 0.036), but the regression analysis did not confirm a significant difference related to ethnicity. Considering the whole population, male gender (OR, 4.036; 95% CI, 1.926–8.456; p < 0.005), a longer disease duration (OR, 2.61; 95% CI, 1.024–6.653; p = 0.044), and a higher axial score (OR, 1.242; 95% CI, 1.122–1.375; p < 0.0005) were the factors associated with axial PA. Conclusion: The prevalence of axial PA in PD patients is not influenced by ethnicity. However, Asian PD patients tend to develop PA earlier in the disease course, particularly AC.