Study on serum transcobalamin II in patients with murine typhus
Issued Date
2005
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Cheeraratana Cheeramakara, จีระรัตน์ จีระมะกร, Kriyaporn Songmeang, กริยาพร สองเมือง, Wanyarat Thanomsak, วัลยารัตน์ ถนอมศักดิ์, Apichart Nontpraset, อภิชาต นนท์ประเสริฐ, Nopachai Suthisai, นภชัย สุทธิสัย, Charnnarong Sanghirun, ชาญณรงค์ แสงหิรัญ, Suvit Areekul, สุวิทย์ อารีย์กูล (2005). Study on serum transcobalamin II in patients with murine typhus. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/63366
Title
Study on serum transcobalamin II in patients with murine typhus
Abstract
We measured the serum transcobalamin II in murine typhus- infected patients (n = 16) admitted to the Hospital for Tropical Diseases in 1996-1997, compared with healthy controls (n = 60). The results showed that the transcobalamin II (TCII) and total serum unsaturated vitaminB12 binding capacity (UBBC) in patients with murine typhus (2,126.5 pg/ml, range 1,262-4,568 and 3,771.5 pg/ml, range 1,576-6,763 pg/ml) were statistically significantly higher than normal subjects (987.5 pg/ml, range 678-2,000 pg/ml and 1,402 pg/ml, range 932-2,470 ml) (p<0.001). Serum TCII levels in patients (63%) were elevated during the febrile period and returned to normal post-treatment. These findings suggest that patients with murine typhus had stimulation of reticulo-endothelial system, spleen, mesenteric lymph nodes, liver and skin and then released TCII into the blood circulation. The elevation in TCII may be used for confirming a diagnosis of murine typhus.
Description
Joint International Tropical Medicine Meeting 2005: The Grand Hotel, Bangkok, Thailand 30 November – 2 December 2005: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2005. p.252.