Exploring the in vitro hypolipidemic benefits of bamboo mushrooms: A study on their impact on lipid droplets and adipocytokine levels through metabolome and lipidome profiling
Issued Date
2025-03-01
Resource Type
eISSN
23523646
Scopus ID
2-s2.0-85213045079
Journal Title
NFS Journal
Volume
38
Rights Holder(s)
SCOPUS
Bibliographic Citation
NFS Journal Vol.38 (2025)
Suggested Citation
Krobthong S., Yingchutrakul Y., Chaichana C., Samutrtai P., Siriwaseree J., Choowongkomon K., Pongkorpsakol P., Maiuthed A., Chanvorachote P., Aonbangkhen C. Exploring the in vitro hypolipidemic benefits of bamboo mushrooms: A study on their impact on lipid droplets and adipocytokine levels through metabolome and lipidome profiling. NFS Journal Vol.38 (2025). doi:10.1016/j.nfs.2024.100211 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102972
Title
Exploring the in vitro hypolipidemic benefits of bamboo mushrooms: A study on their impact on lipid droplets and adipocytokine levels through metabolome and lipidome profiling
Corresponding Author(s)
Other Contributor(s)
Abstract
Functional foods from edible mushrooms, like the protein-rich and low-calorie Phallus indusiatus (Bamboo mushroom), are promising for obesity prevention. However, scientific evidence supporting its active compounds' benefits is limited. This study used tandem-mass spectroscopy (LC-MS/MS) to analyze Bamboo mushroom's metabolites and lipids, identifying over 1000 metabolites, with adenosine most abundant. Pathway analysis showed significant activity in amino acid and specific metabolism pathways. Lipidomic analysis revealed 131 molecular lipids across categories such as sphingolipids and glycerolipids. The extracts' cytotoxicity and hypolipidemic efficacy were evaluated using a mouse adipocytes model, demonstrating no cellular toxicity at 6.25–100 μg/mL and effective reduction in lipid droplets. Additionally, the extracts significantly reduced levels of monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1), suggesting potential hypolipidemic effects. These findings highlight Bamboo mushroom's capability as a functional food to combat obesity by influencing lipid metabolism.